Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 15/20 | 0.53 |
| ▸ | CLK2 | P49760 | 1/20 | 0.53 |
| ▸ | ITK | Q08881 | 3/20 | 0.42 |
| ▸ | KIT | P10721 | 2/20 | 0.42 |
| ▸ | SRC | P12931 | 2/20 | 0.42 |
| ▸ | FLT3 | P36888 | 2/20 | 0.42 |
| ▸ | CDK4 | P11802 | 1/20 | 0.38 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | TTK | P33981 | 1/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12602943 | 0.88 | BTK (0.69) | BTKCLK2 | |
| SCHEMBL13894038 | 0.83 | ITK (0.47) | BTKCLK2ITKKITSRC | |
| SCHEMBL13894051 | 0.83 | BTK (0.67) | BTKCLK2SRC | |
| SCHEMBL13894115 | 0.82 | BTK (0.63) | BTKCLK2ITKSRC | |
| SCHEMBL13894012 | 0.82 | BTK (0.78) | BTKCLK2ITKSRCFLT3 | |
| SCHEMBL13894023 | 0.82 | BTK (0.67) | BTKCLK2 | |
| SCHEMBL13894124 | 0.81 | BTK (0.65) | BTKCLK2SRC | |
| SCHEMBL13894117 | 0.81 | ITK (0.53) | BTKCLK2ITKKITSRC | |
| SCHEMBL13894056 | 0.80 | BTK (0.68) | BTKCLK2ITKSRCFLT3 | |
| SCHEMBL105668 | 0.78 | BTK (0.83) | BTKCLK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009053269-A1 | NOVEL KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-04-30 | — | — | WO | disclosed |