Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 4/20 | 0.34 |
| ▸ | HTR2A | P28223 | 3/20 | 0.34 |
| ▸ | HTR2B | P41595 | 3/20 | 0.34 |
| ▸ | NR3C1 | P04150 | 4/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
| ▸ | PPARG | P37231 | 3/20 | 0.32 |
| ▸ | PPARA | Q07869 | 3/20 | 0.32 |
| ▸ | PPARD | Q03181 | 2/20 | 0.32 |
| ▸ | TTR | P02766 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL91228 | 0.84 | PKM (0.47) | NR3C1CYP1A2CYP2C9SMN1; SMN2TDP1 | |
| SCHEMBL91239 | 0.82 | FFAR1 (0.40) | HTR2CHTR2AHTR2BNR3C1PPARG | |
| SCHEMBL12667924 | 0.81 | HTR2C (0.34) | HTR2CHTR2AHTR2BPPARGPPARA | |
| SCHEMBL12668175 | 0.80 | HTR2B (0.31) | HTR2CHTR2AHTR2BPPARGPPARA | |
| SCHEMBL13894252 | 0.80 | PRSS1 (0.48) | — | |
| SCHEMBL12667522 | 0.74 | GRM2 (0.39) | PPARD | |
| SCHEMBL12667539 | 0.73 | L3MBTL1 (0.37) | TTRCYP1A2CYP2C9TDP1 | |
| SCHEMBL12668859 | 0.71 | IDO1 (0.38) | HTR2BPPARGPPARATTRCYP1A2 | |
| SCHEMBL13884174 | 0.71 | CYP1A2 (0.54) | HTR2BCYP1A2CYP2C9TDP1NR1I2 | |
| Water SCHEMBL27776397 | 0.71 | HTR2C (0.47) | HTR2CHTR2AHTR2BCYP1A2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7521420-B2 | Macrocyclic antagonists of the motilin receptor | TRANZYME PHARMA, INC. (CA) | 2009-04-21 | — | — | US | disclosed |