Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.78 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.78 |
| ▸ | LMNA | P02545 | 4/20 | 0.78 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.78 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.67 |
| ▸ | HTT | P42858 | 1/20 | 0.67 |
| ▸ | MEN1 | O00255 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 4/20 | 0.54 |
| ▸ | L3MBTL4 | Q8NA19 | 1/20 | 0.48 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.48 |
| ▸ | RBP4 | P02753 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17501732 | 0.91 | KDM4E (0.78) | KDM4EALDH1A1LMNASMN1; SMN2MAPK1 | |
| SCHEMBL12409192 | 0.82 | LMNA (0.62) | KDM4EALDH1A1LMNASMN1; SMN2MAPK1 | |
| Hydrochloric Acid SCHEMBL2176957 | 0.81 | LMNA (0.60) | KDM4EALDH1A1LMNASMN1; SMN2MAPK1 | |
| SCHEMBL12409191 | 0.79 | KDM4E (0.62) | KDM4EALDH1A1LMNASMN1; SMN2MAPK1 | |
| SCHEMBL12409162 | 0.78 | MAPT (0.65) | KDM4EALDH1A1LMNASMN1; SMN2MAPK1 | |
| SCHEMBL1900625 | 0.77 | KDM4E (0.67) | KDM4EALDH1A1LMNASMN1; SMN2MAPK1 | |
| SCHEMBL2173939 | 0.77 | KDM4E (0.61) | KDM4EALDH1A1LMNASMN1; SMN2MAPK1 | |
| SCHEMBL8003240 | 0.76 | MAPT (0.59) | KDM4EALDH1A1LMNASMN1; SMN2MAPK1 | |
| SCHEMBL1901227 | 0.76 | KDM4E (0.65) | KDM4EALDH1A1LMNASMN1; SMN2MAPK1 | |
| SCHEMBL12401838 | 0.76 | LMNA (0.57) | KDM4EALDH1A1LMNASMN1; SMN2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009042444-A2 | METHODS AND COMPOUNDS FOR TREATING RETINOL-RELATED DISEASES | SIRION THERAPEUTICS, INC. (US) | 2009-04-02 | — | — | WO | disclosed |