Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 5/20 | 0.38 |
| ▸ | NR1H3 | Q13133 | 5/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.37 |
| ▸ | GCKR | Q14397 | 3/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | CXCR3 | P49682 | 6/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 2/20 | 0.34 |
| ▸ | SGPL1 | O95470 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5778752 | 0.79 | NR1H2 (0.40) | NR1H2NR1H3GPR119GCKRCXCR3 | |
| SCHEMBL12749864 | 0.78 | NR1H2 (0.38) | NR1H2NR1H3GPR119PKMCXCR3 | |
| SCHEMBL1471200 | 0.78 | NR1H2 (0.38) | NR1H2NR1H3GPR119PKMCXCR3 | |
| SCHEMBL5746016 | 0.78 | NR1H2 (0.46) | NR1H2NR1H3GPR119SGPL1 | |
| SCHEMBL12749863 | 0.78 | GPR119 (0.41) | NR1H2NR1H3GPR119GCKRCXCR3 | |
| SCHEMBL1470499 | 0.78 | GPR119 (0.41) | NR1H2NR1H3GPR119GCKRCXCR3 | |
| SCHEMBL5768967 | 0.76 | PPARG (0.41) | NR1H2NR1H3GPR119KDM4ECNR2 | |
| SCHEMBL20308934 | 0.74 | HMOX1 (0.38) | NR1H2NR1H3GPR119GCKRCXCR3 | |
| SCHEMBL13940340 | 0.72 | HMOX1 (0.37) | NR1H2NR1H3GPR119GCKRCXCR3 | |
| SCHEMBL12828183 | 0.68 | TBXA2R (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7517884-B2 | {5-[4-(4-Trifluoromethyl-phenyl)-piperazine-1-sulfonyl]-indan-2-yl}-acetic acid; peroxisome proliferator activated receptors modulator; antidiabetic, antiinflammatory agent; obesity, hyperinsulinemia, metabolic syndrome X, polycystic ovary syndrome, ischemia-associated organ injury, diabetes | KALYPSYS INC. (US) | 2009-04-14 | — | — | US | disclosed |