Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 12/20 | 0.65 |
| ▸ | NPC1 | O15118 | 11/20 | 0.65 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.62 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.62 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.62 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.62 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.62 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.62 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.62 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.62 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.62 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.62 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.62 |
| ▸ | ESRRG | P62508 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.57 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15676745 | 0.91 | RAB9A (0.74) | RAB9ANPC1HDAC2HDAC8HDAC6 | |
| SCHEMBL10160200 | 0.85 | KDM5B (0.69) | RAB9ANPC1HDAC2HDAC8HDAC6 | |
| SCHEMBL28699553 | 0.85 | RAB9A (0.83) | RAB9ANPC1HDAC2HDAC8HDAC6 | |
| SCHEMBL13040551 | 0.84 | HDAC6 (0.60) | RAB9AHDAC2HDAC8HDAC6HDAC3 | |
| SCHEMBL10160158 | 0.84 | KDM4E (0.66) | RAB9ANPC1HDAC2HDAC8HDAC6 | |
| SCHEMBL13439903 | 0.84 | RAB9A (0.74) | RAB9ANPC1HDAC2HDAC8HDAC6 | |
| SCHEMBL12993432 | 0.84 | RAB9A (0.74) | RAB9ANPC1HDAC2HDAC8HDAC6 | |
| SCHEMBL1696410 | 0.84 | NPC1 (0.72) | RAB9ANPC1HDAC2HDAC8HDAC6 | |
| SCHEMBL751214 | 0.84 | HDAC2 (0.80) | RAB9ANPC1HDAC2HDAC8HDAC6 | |
| SCHEMBL5724291 | 0.83 | CA1 (0.69) | RAB9ANPC1HDAC2HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7514468-B2 | Indolinone derivatives substituted in the 6 position, the preparation thereof and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2009-04-07 | — | — | US | disclosed |