Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.66 |
| ▸ | KDM5A | P29375 | 1/20 | 0.66 |
| ▸ | KDM5C | P41229 | 1/20 | 0.66 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.66 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.66 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.66 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.66 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.66 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.66 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.66 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.66 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.66 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.66 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.66 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.66 |
| ▸ | RAB9A | P51151 | 8/20 | 0.64 |
| ▸ | NPC1 | O15118 | 7/20 | 0.64 |
| ▸ | MYC | P01106 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11445651 | 0.90 | NPC1 (0.59) | KDM4EKDM5AKDM5CKDM5BHDAC2 | |
| SCHEMBL751214 | 0.86 | HDAC2 (0.80) | HDAC2HDAC8HDAC6HDAC3HDAC4 | |
| SCHEMBL5724291 | 0.86 | CA1 (0.69) | HDAC2HDAC8HDAC6HDAC3HDAC4 | |
| SCHEMBL10160200 | 0.85 | KDM5B (0.69) | KDM5BHDAC2HDAC8HDAC6HDAC3 | |
| SCHEMBL7282271 | 0.85 | HDAC2 (0.78) | KDM4EKDM5AKDM5CKDM5BHDAC2 | |
| Hydrochloric Acid SCHEMBL28193721 | 0.84 | HDAC2 (0.77) | HDAC2HDAC8HDAC6HDAC3HDAC4 | |
| SCHEMBL13895347 | 0.84 | RAB9A (0.65) | HDAC2HDAC8HDAC6HDAC3HDAC4 | |
| SCHEMBL10160181 | 0.84 | HDAC2 (0.62) | HDAC2HDAC8HDAC6HDAC3HDAC4 | |
| SCHEMBL28699553 | 0.84 | RAB9A (0.83) | KDM4EHDAC2HDAC8HDAC6HDAC3 | |
| SCHEMBL9754524 | 0.84 | HDAC2 (0.62) | HDAC2HDAC8HDAC6HDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105008355-B | Azaindole derivatives as protein kinase inhibitors | 奥里巴斯医药公司 | 2017-08-04 | — | — | CN | disclosed |
| CN-105008355-A | Azaindole derivatives as protein kinase inhibitors | ORIBASE PHARMA | 2015-10-28 | — | — | CN | disclosed |
| US-8093266-B2 | Rho kinase inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-01-10 | — | — | US | disclosed |
| US-20100041645-A1 | RHO KINASE INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-02-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100041645-A1 | RHO KINASE INHIBITORS | CIT, ROCK1, RHOT2 | KDM4E 571/4885KDM5A 917/4885KDM5C 1389/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.