Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 6/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.32 |
| ▸ | PRCP | P42785 | 1/20 | 0.31 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.31 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.31 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.30 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1389702 | 1.00 | GPBAR1 (0.57) | GPBAR1KMT2APROKR1KCNH2PRCP | |
| SCHEMBL1389700 | 1.00 | GPBAR1 (0.57) | GPBAR1KMT2APROKR1KCNH2PRCP | |
| SCHEMBL365143 | 1.00 | GPBAR1 (0.57) | GPBAR1KMT2APROKR1KCNH2PRCP | |
| SCHEMBL363424 | 1.00 | GPBAR1 (0.57) | GPBAR1KMT2APROKR1KCNH2PRCP | |
| SCHEMBL1389708 | 1.00 | GPBAR1 (0.57) | GPBAR1KMT2APROKR1KCNH2PRCP | |
| SCHEMBL10290855 | 0.92 | GPBAR1 (0.59) | GPBAR1KMT2APROKR1KCNH2KDM4C | |
| SCHEMBL1389651 | 0.91 | GPBAR1 (0.58) | GPBAR1KMT2APROKR1KDM4CKDM5B | |
| SCHEMBL363466 | 0.91 | GPBAR1 (0.58) | GPBAR1KMT2APROKR1KDM4CKDM5B | |
| SCHEMBL364545 | 0.91 | GPBAR1 (0.58) | GPBAR1KMT2APROKR1KDM4CKDM5B | |
| SCHEMBL1389653 | 0.91 | GPBAR1 (0.58) | GPBAR1KMT2APROKR1KDM4CKDM5B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593426-B1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | HOFFMANN LA ROCHE (CH) | 2014-08-20 | — | — | EP | claimed |
| EP-2593426-B1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | HOFFMANN LA ROCHE (CH) | 2014-08-20 | — | — | EP | disclosed |
| US-8765730-B2 | 1-hydroxyimino-3-phenyl-propanes | Hoffmann-La Roche Inc (US) | 2014-07-01 | — | — | US | disclosed |
| US-20120010190-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-01-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120010190-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | GPBAR1, GPR119, ADRB1 | GPBAR1 1/4885KMT2A 3981/4885PROKR1 242/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.