Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | XDH | P47989 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.34 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.34 |
| ▸ | AKT1 | P31749 | 1/20 | 0.34 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.33 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3864350 | 1.00 | CISD1 (0.48) | CISD1MEN1KMT2AXDHALOX5 | |
| SCHEMBL3868935 | 1.00 | CISD1 (0.48) | CISD1MEN1KMT2AXDHALOX5 | |
| SCHEMBL3862753 | 0.88 | CISD1 (0.44) | CISD1MEN1KMT2AXDHALOX5 | |
| SCHEMBL3862750 | 0.88 | CISD1 (0.44) | CISD1MEN1KMT2AXDHALOX5 | |
| SCHEMBL13897315 | 0.88 | CISD1 (0.44) | CISD1MEN1KMT2AXDHALOX5 | |
| SCHEMBL5505339 | 0.87 | CISD1 (0.48) | CISD1MEN1KMT2AXDHALOX5 | |
| SCHEMBL5505342 | 0.87 | CISD1 (0.48) | CISD1MEN1KMT2AXDHALOX5 | |
| SCHEMBL14437310 | 0.87 | CISD1 (0.48) | CISD1MEN1KMT2AXDHALOX5 | |
| SCHEMBL14452267 | 0.83 | CISD1 (0.46) | CISD1MEN1KMT2AXDHALOX5 | |
| SCHEMBL5505672 | 0.83 | CISD1 (0.46) | CISD1MEN1KMT2AXDHALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7501428-B2 | e.g. 2-(1-hydroxymethyl-2-phenyl-ethylamino)-5-[1-quinazolin-6-yl-methylidene]-thiazol-4-one; cyclin-dependent kinases (CDKs)/serine-threonine protein kinases inhibitor; antiproliferative, anticarcinogenic, antitumor agent | HOFFMANN-LA ROCHE INC. (US) | 2009-03-10 | — | — | US | claimed |
| EP-1802614-A1 | QUINAZOLINYLMETHYLENETHIAZOLINONES AS CDK1 INHIBITORS | F. Hoffmann-Roche AG (CH) | 2007-07-04 | — | — | EP | claimed |
| WO-2006040050-A1 | QUINAZOLINYLMETHYLENE THIAZOLINONES AS CDK1 INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2006-04-20 | — | — | WO | claimed |
| US-20060084804-A1 | Quinazoline thiazolinones | CHEN LI | 2006-04-20 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060084804-A1 | Quinazoline thiazolinones | CDK1, CDK14, CDK18 | CISD1 1093/4885MEN1 1847/4885KMT2A 1225/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.