Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 3/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.45 |
| ▸ | NQO2 | P16083 | 5/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | G6PD | P11413 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KRAS | P01116 | 4/20 | 0.40 |
| ▸ | SOS1 | Q07889 | 4/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
| ▸ | FBP1 | P09467 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13899607 | 0.89 | PDE4A (0.55) | PDE4APDE4DNQO2LMNAPOLB | |
| SCHEMBL20511938 | 0.81 | PDE4A (0.44) | PDE4APDE4DNQO2MAPTNPC1 | |
| SCHEMBL26037134 | 0.78 | KRAS (0.49) | PDE4APDE4DLMNAKRASSOS1 | |
| SCHEMBL24792134 | 0.77 | PDE4A (0.51) | PDE4APDE4DNQO2MAPTNPC1 | |
| SCHEMBL30076060 | 0.74 | NQO2 (0.41) | PDE4APDE4DNQO2MAPTNPC1 | |
| SCHEMBL27248572 | 0.74 | NQO2 (0.41) | PDE4APDE4DNQO2MAPTNPC1 | |
| SCHEMBL27253863 | 0.74 | DHFR (0.50) | PDE4APDE4DMAPTLMNAPOLB | |
| SCHEMBL23004817 | 0.74 | PDE4A (0.44) | PDE4APDE4DNQO2MAPTKRAS | |
| SCHEMBL372023 | 0.73 | PDE4A (0.62) | PDE4APDE4DNQO2LMNAPOLB | |
| SCHEMBL13335780 | 0.72 | PDE4A (0.57) | PDE4APDE4DNQO2NPC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7504397-B2 | mTOR inhibitor compounds | KUDOS PHARMACEUTICALS LTD. (GB) | 2009-03-17 | — | — | US | disclosed |