Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 3/20 | 0.55 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.55 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.49 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.49 |
| ▸ | KRAS | P01116 | 4/20 | 0.48 |
| ▸ | SOS1 | Q07889 | 4/20 | 0.48 |
| ▸ | EGFR | P00533 | 1/20 | 0.48 |
| ▸ | FBP1 | P09467 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | NQO2 | P16083 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | WHR1 | P49842 | 1/20 | 0.41 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.41 |
| ▸ | TUBB | P07437 | 1/20 | 0.41 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13899644 | 0.89 | PDE4A (0.45) | PDE4APDE4DPDE3BPDE3AKRAS | |
| SCHEMBL372023 | 0.83 | PDE4A (0.62) | PDE4APDE4DPDE3BPDE3AKRAS | |
| SCHEMBL13335780 | 0.82 | PDE4A (0.57) | PDE4APDE4DPDE3BPDE3AKRAS | |
| SCHEMBL8140684 | 0.81 | PDE4A (0.55) | PDE4APDE4DPDE3BPDE3AKRAS | |
| SCHEMBL372259 | 0.79 | PDE4A (0.54) | PDE4APDE4DPDE3BPDE3AKRAS | |
| SCHEMBL3265628 | 0.79 | POLB (0.61) | PDE4APDE4DPOLBLMNAGLA | |
| SCHEMBL20813455 | 0.79 | PDE4A (0.54) | PDE4APDE4DPDE3BPDE3AKRAS | |
| SCHEMBL29723105 | 0.79 | PDE4A (0.54) | PDE4APDE4DPDE3BPDE3AKRAS | |
| SCHEMBL28607756 | 0.78 | PDE4A (0.53) | PDE4APDE4DPDE3BPDE3AKRAS | |
| SCHEMBL27866061 | 0.78 | PDE4A (0.53) | PDE4APDE4DPDE3BPDE3AKRAS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7504397-B2 | mTOR inhibitor compounds | KUDOS PHARMACEUTICALS LTD. (GB) | 2009-03-17 | — | — | US | disclosed |