Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.46 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.38 |
| ▸ | PTGER4 | P35408 | 4/20 | 0.35 |
| ▸ | PTGDR | Q13258 | 3/20 | 0.35 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.34 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.34 |
| ▸ | F11 | P03951 | 2/20 | 0.34 |
| ▸ | PHGDH | O43175 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.33 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1389988 | 1.00 | GPBAR1 (0.46) | GPBAR1CREBBPPTGER4PTGDRKEAP1 | |
| SCHEMBL1389985 | 1.00 | GPBAR1 (0.46) | GPBAR1CREBBPPTGER4PTGDRKEAP1 | |
| SCHEMBL1390130 | 0.97 | GPBAR1 (0.51) | GPBAR1CREBBPPTGER4PTGDRKEAP1 | |
| SCHEMBL10241335 | 0.97 | GPBAR1 (0.51) | GPBAR1CREBBPPTGER4PTGDRKEAP1 | |
| SCHEMBL369930 | 0.97 | GPBAR1 (0.51) | GPBAR1CREBBPPTGER4PTGDRKEAP1 | |
| SCHEMBL369931 | 0.97 | GPBAR1 (0.51) | GPBAR1CREBBPPTGER4PTGDRKEAP1 | |
| SCHEMBL10241339 | 0.97 | GPBAR1 (0.51) | GPBAR1CREBBPPTGER4PTGDRKEAP1 | |
| SCHEMBL15832829 | 0.92 | GPBAR1 (0.40) | GPBAR1CREBBPKEAP1NFE2L2EGFR | |
| SCHEMBL370281 | 0.91 | GPBAR1 (0.51) | GPBAR1CREBBPKEAP1NFE2L2EGFR | |
| SCHEMBL370280 | 0.91 | GPBAR1 (0.51) | GPBAR1CREBBPKEAP1NFE2L2EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593426-B1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | HOFFMANN LA ROCHE (CH) | 2014-08-20 | — | — | EP | claimed |
| EP-2593426-B1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | HOFFMANN LA ROCHE (CH) | 2014-08-20 | — | — | EP | disclosed |
| US-8765730-B2 | 1-hydroxyimino-3-phenyl-propanes | Hoffmann-La Roche Inc (US) | 2014-07-01 | — | — | US | disclosed |
| US-20120010190-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-01-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120010190-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | GPBAR1, GPR119, ADRB1 | GPBAR1 1/4885CREBBP 2198/4885PTGER4 103/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.