Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 15/20 | 0.54 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.54 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.54 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.54 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | ABCB4 | P21439 | 1/20 | 0.54 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.54 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.54 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | LPAR3 | Q9UBY5 | 3/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.33 |
| ▸ | TET3 | O43151 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | FBXL19 | Q6PCT2 | 1/20 | 0.31 |
| ▸ | CXXC5 | Q7LFL8 | 1/20 | 0.31 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7404 | 0.82 | LPAR1 (0.61) | LPAR1ABCC3ABCC4ABCB11CYP2C8 | |
| SCHEMBL10560 | 0.79 | LPAR1 (0.61) | LPAR1ABCC3ABCC4ABCB11CYP2C8 | |
| SCHEMBL2761256 | 0.77 | LPAR1 (0.73) | LPAR1ABCC3ABCC4ABCB11CYP2C8 | |
| SCHEMBL18597706 | 0.77 | LPAR1 (0.63) | LPAR1ABCC3ABCC4ABCB11CYP2C8 | |
| SCHEMBL8070 | 0.76 | LPAR1 (0.64) | LPAR1ABCC3ABCC4ABCB11CYP2C8 | |
| SCHEMBL18746088 | 0.76 | LPAR1 (0.52) | LPAR1ABCC3ABCC4ABCB11CYP2C8 | |
| SCHEMBL6508 | 0.76 | LPAR1 (0.58) | LPAR1ABCC3ABCC4ABCB11CYP2C8 | |
| SCHEMBL6243 | 0.75 | LPAR1 (0.65) | LPAR1ABCC3ABCC4ABCB11CYP2C8 | |
| SCHEMBL5994 | 0.75 | LPAR1 (0.72) | LPAR1ABCC3ABCC4ABCB11CYP2C8 | |
| SCHEMBL18597813 | 0.75 | LPAR1 (0.61) | LPAR1ABCC3ABCC4ABCB11CYP2C8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011041694-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS, INC. (US) | 2011-04-07 | — | — | WO | disclosed |