Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 13/20 | 0.61 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.61 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.61 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.61 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.61 |
| ▸ | ABCB4 | P21439 | 1/20 | 0.61 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.61 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.61 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | LPAR3 | Q9UBY5 | 4/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | TAS2R8 | Q9NYW2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8070 | 0.82 | LPAR1 (0.64) | LPAR1ABCC3ABCC4ABCB11CYP2C8 | |
| SCHEMBL10560 | 0.81 | LPAR1 (0.61) | LPAR1ABCC3ABCC4ABCB11CYP2C8 | |
| SCHEMBL7404 | 0.81 | LPAR1 (0.61) | LPAR1ABCC3ABCC4ABCB11CYP2C8 | |
| SCHEMBL5994 | 0.81 | LPAR1 (0.72) | LPAR1ABCC3ABCC4ABCB11CYP2C8 | |
| SCHEMBL18597908 | 0.81 | LPAR1 (0.72) | LPAR1ABCC3ABCC4ABCB11CYP2C8 | |
| SCHEMBL5995 | 0.80 | LPAR1 (0.61) | LPAR1ABCC3ABCC4ABCB11CYP2C8 | |
| SCHEMBL3633 | 0.79 | LPAR1 (0.64) | LPAR1ABCC3ABCC4ABCB11CYP2C8 | |
| SCHEMBL2761256 | 0.79 | LPAR1 (0.73) | LPAR1ABCC3ABCC4ABCB11CYP2C8 | |
| SCHEMBL4899 | 0.79 | LPAR1 (0.53) | LPAR1ABCC3ABCC4ABCB11CYP2C8 | |
| SCHEMBL18597706 | 0.79 | LPAR1 (0.63) | LPAR1ABCC3ABCC4ABCB11CYP2C8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2483252-B1 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS INC (US) | 2017-03-08 | — | — | EP | disclosed |