Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.43 |
| ▸ | PPARG | P37231 | 7/20 | 0.37 |
| ▸ | CTSA | P10619 | 6/20 | 0.35 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.34 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1390087 | 1.00 | GPBAR1 (0.43) | GPBAR1PPARGCTSALTB4R2NR1I2 | |
| SCHEMBL1390112 | 0.92 | GPBAR1 (0.44) | GPBAR1PPARGCTSAFFAR1 | |
| SCHEMBL1390114 | 0.92 | GPBAR1 (0.44) | GPBAR1PPARGCTSAFFAR1 | |
| SCHEMBL1390207 | 0.91 | GPBAR1 (0.51) | GPBAR1CTSAFFAR1 | |
| SCHEMBL1390206 | 0.91 | GPBAR1 (0.51) | GPBAR1CTSAFFAR1 | |
| SCHEMBL15949295 | 0.89 | GPBAR1 (0.40) | GPBAR1CTSA | |
| SCHEMBL368681 | 0.86 | BDKRB1 (0.41) | GPBAR1 | |
| SCHEMBL1389912 | 0.86 | GPBAR1 (0.40) | GPBAR1CTSAFFAR1 | |
| SCHEMBL1389910 | 0.86 | GPBAR1 (0.40) | GPBAR1CTSAFFAR1 | |
| SCHEMBL15949026 | 0.85 | GPBAR1 (0.41) | GPBAR1CTSAFFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593426-B1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | HOFFMANN LA ROCHE (CH) | 2014-08-20 | — | — | EP | claimed |
| EP-2593426-B1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | HOFFMANN LA ROCHE (CH) | 2014-08-20 | — | — | EP | disclosed |
| US-8765730-B2 | 1-hydroxyimino-3-phenyl-propanes | Hoffmann-La Roche Inc (US) | 2014-07-01 | — | — | US | disclosed |
| US-20120010190-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-01-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120010190-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | GPBAR1, GPR119, ADRB1 | GPBAR1 1/4885PPARG 161/4885CTSA 3225/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.