Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBK1 | Q9UHD2 | 5/20 | 0.66 |
| ▸ | NUAK1 | O60285 | 3/20 | 0.66 |
| ▸ | CSF1R | P07333 | 2/20 | 0.66 |
| ▸ | TYK2 | P29597 | 2/20 | 0.66 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.66 |
| ▸ | STK16 | O75716 | 1/20 | 0.66 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.66 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.66 |
| ▸ | ULK3 | Q6PHR2 | 1/20 | 0.66 |
| ▸ | BMP2K | Q9NSY1 | 1/20 | 0.66 |
| ▸ | PLK4 | O00444 | 1/20 | 0.62 |
| ▸ | MARK3 | P27448 | 3/20 | 0.62 |
| ▸ | MARK4 | Q96L34 | 3/20 | 0.62 |
| ▸ | STK17A | Q9UEE5 | 3/20 | 0.62 |
| ▸ | CDK1 | P06493 | 1/20 | 0.60 |
| ▸ | KDR | P35968 | 1/20 | 0.60 |
| ▸ | ULK2 | Q8IYT8 | 3/20 | 0.55 |
| ▸ | IKBKE | Q14164 | 2/20 | 0.55 |
| ▸ | SIK2 | Q9H0K1 | 2/20 | 0.52 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL270735 | 0.87 | PLK4 (0.60) | TBK1NUAK1CSF1RTYK2NTRK1 | |
| SCHEMBL13897571 | 0.82 | TBK1 (0.68) | TBK1NUAK1CSF1RTYK2NTRK1 | |
| SCHEMBL1571728 | 0.82 | TBK1 (0.58) | TBK1NUAK1CSF1RTYK2NTRK1 | |
| SCHEMBL29370869 | 0.81 | CDK1 (0.63) | TBK1NUAK1CSF1RTYK2NTRK1 | |
| SCHEMBL4875509 | 0.80 | PLK4 (0.64) | TBK1NUAK1CSF1RTYK2NTRK1 | |
| SCHEMBL1571328 | 0.80 | TBK1 (0.53) | TBK1NUAK1CSF1RTYK2NTRK1 | |
| SCHEMBL28153587 | 0.78 | PLK4 (0.56) | TBK1NUAK1CSF1RTYK2NTRK1 | |
| SCHEMBL12423160 | 0.78 | JAK2 (0.61) | TBK1NUAK1CSF1RTYK2NTRK1 | |
| SCHEMBL13897748 | 0.77 | MARK3 (0.74) | TBK1NUAK1CSF1RTYK2NTRK1 | |
| SCHEMBL13901338 | 0.77 | CDK1 (0.53) | TBK1NUAK1CSF1RTYK2NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7504410-B2 | Chk-, Pdk- and Akt-inhibitory pyrimidines, their production and use as pharmaceutical agents | SCHERING AKTIENGESELLSCHAFT (DE) | 2009-03-17 | — | — | US | disclosed |