Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK4 | O00444 | 1/20 | 0.56 |
| ▸ | CDK1 | P06493 | 1/20 | 0.56 |
| ▸ | KDR | P35968 | 1/20 | 0.56 |
| ▸ | JAK2 | O60674 | 3/20 | 0.53 |
| ▸ | JAK3 | P52333 | 3/20 | 0.53 |
| ▸ | NUAK1 | O60285 | 2/20 | 0.53 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.53 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.53 |
| ▸ | SIK2 | Q9H0K1 | 1/20 | 0.53 |
| ▸ | TBK1 | Q9UHD2 | 3/20 | 0.52 |
| ▸ | CSF1R | P07333 | 2/20 | 0.52 |
| ▸ | TYK2 | P29597 | 2/20 | 0.52 |
| ▸ | ULK2 | Q8IYT8 | 2/20 | 0.52 |
| ▸ | MARK3 | P27448 | 2/20 | 0.52 |
| ▸ | MARK4 | Q96L34 | 2/20 | 0.52 |
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.52 |
| ▸ | NCF1 | P14598 | 1/20 | 0.51 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.50 |
| ▸ | STK16 | O75716 | 1/20 | 0.50 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4875509 | 0.90 | PLK4 (0.64) | PLK4CDK1KDRJAK2JAK3 | |
| SCHEMBL29370869 | 0.79 | CDK1 (0.63) | PLK4CDK1KDRJAK2JAK3 | |
| SCHEMBL13901171 | 0.78 | TBK1 (0.66) | PLK4CDK1KDRJAK2JAK3 | |
| SCHEMBL270735 | 0.78 | PLK4 (0.60) | PLK4CDK1KDRJAK2JAK3 | |
| SCHEMBL4367879 | 0.76 | NCF1 (0.60) | PLK4CDK1KDRJAK2JAK3 | |
| SCHEMBL13946389 | 0.76 | NCF1 (0.65) | PLK4CDK1KDRNUAK1TBK1 | |
| SCHEMBL16662667 | 0.76 | SCN9A (0.56) | PLK4CDK1KDRJAK2JAK3 | |
| SCHEMBL6649769 | 0.76 | ACKR3 (0.65) | ALDH1A1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL4192881 | 0.75 | NCF1 (0.63) | PLK4CDK1KDRNUAK1TBK1 | |
| SCHEMBL11196105 | 0.75 | NCF1 (0.83) | NCF1ALDH1A1KDM4EHPGDHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106715419-A | Aminotriazine derivatives as TANK-binding kinase inhibitor compounds | 吉利德科学公司 | 2017-05-24 | — | — | CN | disclosed |