Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 6/20 | 0.60 |
| ▸ | CDK2 | P24941 | 1/20 | 0.60 |
| ▸ | ULK1 | O75385 | 4/20 | 0.60 |
| ▸ | PDK1 | Q15118 | 4/20 | 0.60 |
| ▸ | ULK2 | Q8IYT8 | 4/20 | 0.60 |
| ▸ | TBK1 | Q9UHD2 | 14/20 | 0.59 |
| ▸ | MARK3 | P27448 | 4/20 | 0.59 |
| ▸ | MARK4 | Q96L34 | 4/20 | 0.59 |
| ▸ | STK17A | Q9UEE5 | 4/20 | 0.59 |
| ▸ | NUAK1 | O60285 | 3/20 | 0.57 |
| ▸ | IKBKE | Q14164 | 2/20 | 0.57 |
| ▸ | CGAS | Q8N884 | 1/20 | 0.57 |
| ▸ | AURKA | O14965 | 1/20 | 0.52 |
| ▸ | TYK2 | P29597 | 3/20 | 0.51 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.51 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.51 |
| ▸ | SIK2 | Q9H0K1 | 2/20 | 0.51 |
| ▸ | STK17B | O94768 | 1/20 | 0.51 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.49 |
| ▸ | BMPR2 | Q13873 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13898307 | 0.92 | PDPK1 (0.72) | PDPK1CDK2ULK1PDK1ULK2 | |
| SCHEMBL13901444 | 0.88 | ULK1 (0.65) | PDPK1CDK2ULK1PDK1ULK2 | |
| SCHEMBL13901495 | 0.87 | ULK1 (0.54) | PDPK1CDK2ULK1PDK1ULK2 | |
| SCHEMBL13901489 | 0.84 | ULK1 (0.68) | PDPK1CDK2ULK1PDK1ULK2 | |
| SCHEMBL13901281 | 0.84 | ULK1 (0.61) | PDPK1CDK2ULK1PDK1ULK2 | |
| SCHEMBL13898232 | 0.84 | TBK1 (0.73) | PDPK1CDK2ULK1PDK1ULK2 | |
| SCHEMBL13898280 | 0.83 | PDPK1 (0.71) | PDPK1CDK2ULK1PDK1ULK2 | |
| SCHEMBL13901545 | 0.83 | ULK1 (0.55) | PDPK1CDK2ULK1PDK1ULK2 | |
| SCHEMBL13901548 | 0.83 | ULK1 (0.64) | PDPK1CDK2ULK1PDK1ULK2 | |
| SCHEMBL13901522 | 0.83 | ULK1 (0.63) | PDPK1CDK2ULK1PDK1ULK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7504410-B2 | Chk-, Pdk- and Akt-inhibitory pyrimidines, their production and use as pharmaceutical agents | SCHERING AKTIENGESELLSCHAFT (DE) | 2009-03-17 | — | — | US | disclosed |