Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ULK1 | O75385 | 3/20 | 0.43 |
| ▸ | PDK1 | Q15118 | 3/20 | 0.43 |
| ▸ | ULK2 | Q8IYT8 | 3/20 | 0.43 |
| ▸ | MET | P08581 | 3/20 | 0.42 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.42 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.42 |
| ▸ | EGFR | P00533 | 4/20 | 0.42 |
| ▸ | JAK3 | P52333 | 1/20 | 0.42 |
| ▸ | STAT6 | P42226 | 1/20 | 0.41 |
| ▸ | BTK | Q06187 | 2/20 | 0.40 |
| ▸ | ITK | Q08881 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | CIT | O14578 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
| ▸ | AKT1 | P31749 | 1/20 | 0.39 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.39 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.38 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.38 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13901511 | 0.93 | TBK1 (0.46) | ULK1PDK1ULK2METALK | |
| SCHEMBL13901366 | 0.92 | CCNT1 (0.44) | ULK1PDK1ULK2METALK | |
| SCHEMBL13901539 | 0.91 | JAK3 (0.43) | ULK1PDK1ULK2METALK | |
| SCHEMBL13901493 | 0.90 | MEN1 (0.41) | ULK1PDK1ULK2METALK | |
| SCHEMBL13898466 | 0.90 | TBK1 (0.53) | ULK1PDK1ULK2METALK | |
| SCHEMBL13901597 | 0.89 | NTRK1 (0.44) | METALKTBK1EGFRJAK3 | |
| SCHEMBL13901471 | 0.89 | MET (0.43) | ULK1PDK1ULK2METALK | |
| SCHEMBL13901594 | 0.88 | BTK (0.45) | METALKTBK1EGFRJAK3 | |
| SCHEMBL13901500 | 0.88 | MET (0.41) | ULK1PDK1ULK2METALK | |
| SCHEMBL13901467 | 0.87 | STAT6 (0.48) | METALKTBK1EGFRJAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7504410-B2 | Chk-, Pdk- and Akt-inhibitory pyrimidines, their production and use as pharmaceutical agents | SCHERING AKTIENGESELLSCHAFT (DE) | 2009-03-17 | — | — | US | disclosed |