Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 5/20 | 0.43 |
| ▸ | CCR9 | P51686 | 3/20 | 0.40 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | MGAM | O43451 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | SI | P14410 | 2/20 | 0.35 |
| ▸ | MGAM2 | Q2M2H8 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1390478 | 1.00 | GPBAR1 (0.43) | GPBAR1CCR9PROKR1ADORA3ADORA2A | |
| SCHEMBL1390416 | 0.88 | GPBAR1 (0.46) | GPBAR1CCR9PROKR1POLBMGAM | |
| SCHEMBL362865 | 0.88 | GPBAR1 (0.55) | GPBAR1CCR9PROKR1POLBMGAM | |
| SCHEMBL1390415 | 0.88 | GPBAR1 (0.46) | GPBAR1CCR9PROKR1POLBMGAM | |
| SCHEMBL1389983 | 0.87 | GPBAR1 (0.56) | GPBAR1CCR9PROKR1ADORA3ADORA2A | |
| SCHEMBL1389984 | 0.87 | GPBAR1 (0.56) | GPBAR1CCR9PROKR1ADORA3ADORA2A | |
| SCHEMBL1389981 | 0.87 | GPBAR1 (0.56) | GPBAR1CCR9PROKR1ADORA3ADORA2A | |
| SCHEMBL1389986 | 0.87 | GPBAR1 (0.56) | GPBAR1CCR9PROKR1ADORA3ADORA2A | |
| SCHEMBL1390696 | 0.87 | GPBAR1 (0.49) | GPBAR1PROKR1POLBMGAMGAA | |
| SCHEMBL370167 | 0.87 | GPBAR1 (0.49) | GPBAR1PROKR1POLBMGAMGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593426-B1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | HOFFMANN LA ROCHE (CH) | 2014-08-20 | — | — | EP | claimed |
| EP-2593426-B1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | HOFFMANN LA ROCHE (CH) | 2014-08-20 | — | — | EP | disclosed |
| US-8765730-B2 | 1-hydroxyimino-3-phenyl-propanes | Hoffmann-La Roche Inc (US) | 2014-07-01 | — | — | US | disclosed |
| US-20120010190-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-01-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120010190-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | GPBAR1, GPR119, ADRB1 | GPBAR1 1/4885CCR9 2832/4885PROKR1 242/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.