Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | ME3 | Q16798 | 1/20 | 0.47 |
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.46 |
| ▸ | HPGDS | O60760 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | CASR | P41180 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
| ▸ | SFRP1 | Q8N474 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3958961 | 0.85 | POLB (0.58) | USP2ME3SMYD3HPGDSMEN1 | |
| SCHEMBL15560163 | 0.84 | SMYD3 (0.59) | USP2ME3SMYD3HPGDSMEN1 | |
| SCHEMBL13906605 | 0.83 | SMN1; SMN2 (0.48) | SMYD3MEN1KMT2APOLBSMN1; SMN2 | |
| SCHEMBL3956681 | 0.80 | GAA (0.53) | USP2MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL8346658 | 0.78 | DRD4 (0.64) | MEN1KMT2APOLBSMN1; SMN2MAPT | |
| SCHEMBL27889141 | 0.75 | ALDH1A1 (0.58) | USP2ME3HPGDSKMT2ACASR | |
| SCHEMBL8351812 | 0.73 | USP2 (0.69) | USP2ME3SMYD3HPGDSMEN1 | |
| SCHEMBL22815724 | 0.73 | POLB (0.56) | ME3SMYD3MEN1KMT2APOLB | |
| SCHEMBL17832734 | 0.72 | LTA4H (0.56) | USP2HPGDSMEN1KMT2ACASR | |
| SCHEMBL3958384 | 0.72 | DRD4 (0.56) | USP2ME3MEN1KMT2ACASR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009036035-A1 | BCL-2 INHIBITORS | CURIS, INC. (US) | 2009-03-19 | — | — | WO | disclosed |