Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.57 |
| ▸ | TP53 | P04637 | 3/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | TSHR | P16473 | 2/20 | 0.57 |
| ▸ | USP2 | O75604 | 2/20 | 0.57 |
| ▸ | MITF | O75030 | 1/20 | 0.57 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | MC4R | P32245 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | CLK1 | P49759 | 1/20 | 0.53 |
| ▸ | GSK3A | P49840 | 1/20 | 0.53 |
| ▸ | GSK3B | P49841 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | RAF1 | P04049 | 7/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3959437 | 0.88 | MAPT (0.58) | MAPTMAPK1SMN1; SMN2TP53ALDH1A1 | |
| SCHEMBL2344153 | 0.87 | MAPT (0.63) | MAPTMAPK1SMN1; SMN2TP53ALDH1A1 | |
| SCHEMBL6185626 | 0.85 | MAPK1 (0.65) | MAPTMAPK1SMN1; SMN2TP53ALDH1A1 | |
| SCHEMBL3959184 | 0.82 | RAF1 (0.61) | MAPTMAPK1SMN1; SMN2TP53ALDH1A1 | |
| SCHEMBL3955158 | 0.82 | MAPT (0.59) | MAPTMAPK1TP53ALDH1A1TDP1 | |
| SCHEMBL3952897 | 0.82 | RAF1 (0.57) | MAPTMAPK1TP53RAF1BRAF | |
| SCHEMBL4240335 | 0.82 | MAPT (0.55) | MAPTMAPK1SMN1; SMN2TP53ALDH1A1 | |
| SCHEMBL5934793 | 0.82 | MAPT (0.63) | MAPTMAPK1SMN1; SMN2TP53ALDH1A1 | |
| SCHEMBL2346099 | 0.81 | MAPK14 (0.60) | MAPTMAPK1SMN1; SMN2TP53ALDH1A1 | |
| SCHEMBL2352743 | 0.81 | MAPT (0.58) | MAPTMAPK1SMN1; SMN2TP53ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009034390-A1 | HETEROCYCLIC DERIVATIVES AND THEIR USE IN TREATING HEPATITIS C | ARROW THERAPEUTICS LIMITED (GB) | 2009-03-19 | — | — | WO | disclosed |