Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.58 |
| ▸ | RAB9A | P51151 | 3/20 | 0.57 |
| ▸ | PKM | P14618 | 2/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.57 |
| ▸ | NPC1 | O15118 | 2/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | ATM | Q13315 | 1/20 | 0.55 |
| ▸ | RARA | P10276 | 1/20 | 0.54 |
| ▸ | RARG | P13631 | 1/20 | 0.54 |
| ▸ | RAF1 | P04049 | 5/20 | 0.54 |
| ▸ | BRAF | P15056 | 5/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6185626 | 0.89 | MAPK1 (0.65) | MAPTRAB9APKMMAPK1NPC1 | |
| SCHEMBL13907630 | 0.88 | MAPT (0.57) | MAPTRAB9APKMMAPK1NPC1 | |
| SCHEMBL3952897 | 0.86 | RAF1 (0.57) | MAPTRAB9APKMMAPK1NPC1 | |
| SCHEMBL3955158 | 0.86 | MAPT (0.59) | MAPTRAB9APKMMAPK1NPC1 | |
| SCHEMBL5934793 | 0.86 | MAPT (0.63) | MAPTRAB9APKMMAPK1NPC1 | |
| SCHEMBL2346560 | 0.85 | RARA (0.66) | MAPTRAB9APKMMAPK1NPC1 | |
| SCHEMBL3963413 | 0.85 | MAPT (0.52) | MAPTRAB9APKMMAPK1NPC1 | |
| SCHEMBL3959184 | 0.85 | RAF1 (0.61) | MAPTRAB9APKMMAPK1NPC1 | |
| SCHEMBL4055744 | 0.84 | MAPK14 (0.62) | MAPTRAB9APKMMAPK1NPC1 | |
| SCHEMBL2913173 | 0.83 | PKM (0.65) | MAPTRAB9APKMMAPK1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009034390-A1 | HETEROCYCLIC DERIVATIVES AND THEIR USE IN TREATING HEPATITIS C | ARROW THERAPEUTICS LIMITED (GB) | 2009-03-19 | — | — | WO | disclosed |
| WO-2009034390-A1 | HETEROCYCLIC DERIVATIVES AND THEIR USE IN TREATING HEPATITIS C | ARROW THERAPEUTICS LIMITED (GB) | 2009-03-19 | — | — | WO | disclosed |