Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | PREP | P48147 | 1/20 | 0.32 |
| ▸ | TPSAB1 | Q15661 | 2/20 | 0.31 |
| ▸ | TPSD1 | Q9BZJ3 | 2/20 | 0.31 |
| ▸ | TPSG1 | Q9NRR2 | 2/20 | 0.31 |
| ▸ | ATM | Q13315 | 2/20 | 0.31 |
| ▸ | CTSK | P43235 | 1/20 | 0.31 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.30 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.30 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22950787 | 1.00 | LMNA (0.35) | LMNANPSR1CYP1A2POLBCYP3A4 | |
| SCHEMBL4040236 | 0.81 | NR1H2 (0.37) | LMNANPSR1CYP1A2POLBCYP3A4 | |
| SCHEMBL4040230 | 0.81 | NR1H2 (0.37) | LMNANPSR1CYP1A2POLBCYP3A4 | |
| SCHEMBL4049132 | 0.80 | PREP (0.35) | LMNANPSR1CYP1A2POLBCYP3A4 | |
| SCHEMBL4049137 | 0.80 | PREP (0.35) | LMNANPSR1CYP1A2POLBCYP3A4 | |
| SCHEMBL24821656 | 0.78 | NR1H2 (0.42) | LMNANPSR1CYP1A2POLBCYP3A4 | |
| SCHEMBL2227084 | 0.78 | NR1H2 (0.42) | LMNANPSR1CYP1A2POLBCYP3A4 | |
| SCHEMBL1639634 | 0.78 | NR1H2 (0.42) | LMNANPSR1CYP1A2POLBCYP3A4 | |
| SCHEMBL4045705 | 0.76 | GPR119 (0.37) | PREPNR1H2 | |
| SCHEMBL22950789 | 0.74 | GPR119 (0.38) | ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-B1 | PYRROLE DERIVATIVES AS INHIBITORS OF CYTEINE PROTEASES | AMURA THERAPEUTICS LTD (GB) | 2009-03-04 | — | — | EP | disclosed |
| WO-2004007501-A1 | BIOLOGICALLY ACTIVE COMPOUNDS | AMURA THERAPEUTICS LIMITED (GB) | 2004-01-22 | — | — | WO | disclosed |