Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 13/20 | 0.77 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.42 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.42 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.42 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.42 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.42 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13910485 | 0.90 | GSK3B (0.85) | GSK3B | |
| SCHEMBL13910329 | 0.90 | GSK3B (0.89) | GSK3B | |
| SCHEMBL13910464 | 0.89 | GSK3B (0.73) | GSK3B | |
| SCHEMBL13910418 | 0.89 | GSK3B (0.77) | GSK3BCYP2D6 | |
| SCHEMBL13910835 | 0.88 | GSK3B (0.82) | GSK3BPOLB | |
| SCHEMBL13910315 | 0.88 | GSK3B (0.82) | GSK3B | |
| SCHEMBL13910495 | 0.88 | GSK3B (0.71) | GSK3B | |
| SCHEMBL13910833 | 0.87 | GSK3B (0.80) | GSK3B | |
| SCHEMBL4028335 | 0.87 | GSK3B (1.00) | GSK3BCYP2D6 | |
| SCHEMBL14063466 | 0.87 | GSK3B (0.80) | GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1427720-B1 | 3-SUBSTITUTED-4-PYRIMIDONE DERIVATIVES | MITSUBISHI TANABE PHARMA CORP (JP) | 2009-03-04 | — | — | EP | disclosed |
| US-7427615-B2 | 3-substituted-4-pyrimidone derivatives | MITSUBISHI PHARMA CORPORATION (JP) | 2008-09-23 | — | — | US | disclosed |
| US-7427615-B2 | 3-substituted-4-pyrimidone derivatives | MITSUBISHI PHARMA CORPORATION (JP) | 2008-09-23 | — | — | US | disclosed |