Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 12/20 | 0.77 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | BRAF | P15056 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13910432 | 0.90 | GSK3B (0.74) | GSK3B | |
| SCHEMBL13910314 | 0.89 | GSK3B (0.77) | GSK3BCYP2D6 | |
| SCHEMBL13910845 | 0.88 | GSK3B (0.83) | GSK3B | |
| SCHEMBL13721715 | 0.88 | GSK3B (0.59) | GSK3BMAPTALDH1A1CYP2D6TSHR | |
| SCHEMBL4034257 | 0.87 | GSK3B (1.00) | GSK3B | |
| SCHEMBL4028435 | 0.87 | GSK3B (1.00) | GSK3B | |
| SCHEMBL13910437 | 0.86 | GSK3B (0.68) | GSK3B | |
| SCHEMBL14063487 | 0.86 | GSK3B (0.69) | GSK3B | |
| SCHEMBL13910440 | 0.86 | GSK3B (0.86) | GSK3B | |
| SCHEMBL4029186 | 0.86 | GSK3B (1.00) | GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1427720-B1 | 3-SUBSTITUTED-4-PYRIMIDONE DERIVATIVES | MITSUBISHI TANABE PHARMA CORP (JP) | 2009-03-04 | — | — | EP | disclosed |
| US-7427615-B2 | 3-substituted-4-pyrimidone derivatives | MITSUBISHI PHARMA CORPORATION (JP) | 2008-09-23 | — | — | US | disclosed |
| US-7427615-B2 | 3-substituted-4-pyrimidone derivatives | MITSUBISHI PHARMA CORPORATION (JP) | 2008-09-23 | — | — | US | disclosed |