Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 11/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.42 |
| ▸ | WNT3A | P56704 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13910467 | 0.91 | GSK3B (0.74) | GSK3B | |
| SCHEMBL13910314 | 0.88 | GSK3B (0.77) | GSK3B | |
| SCHEMBL13722027 | 0.87 | GSK3B (0.55) | GSK3BSMN1; SMN2CTNNB1WNT3A | |
| SCHEMBL13910485 | 0.86 | GSK3B (0.85) | GSK3B | |
| SCHEMBL13910329 | 0.86 | GSK3B (0.89) | GSK3B | |
| SCHEMBL13910418 | 0.85 | GSK3B (0.77) | GSK3BSMN1; SMN2ALDH1A1 | |
| SCHEMBL13910423 | 0.85 | GSK3B (0.69) | GSK3B | |
| SCHEMBL13910421 | 0.84 | GSK3B (0.64) | GSK3BMEN1ALDH1A1KMT2A | |
| SCHEMBL13910835 | 0.84 | GSK3B (0.82) | GSK3BPKM | |
| SCHEMBL13910315 | 0.84 | GSK3B (0.82) | GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1427720-B1 | 3-SUBSTITUTED-4-PYRIMIDONE DERIVATIVES | MITSUBISHI TANABE PHARMA CORP (JP) | 2009-03-04 | — | — | EP | disclosed |
| US-7427615-B2 | 3-substituted-4-pyrimidone derivatives | MITSUBISHI PHARMA CORPORATION (JP) | 2008-09-23 | — | — | US | disclosed |
| US-7427615-B2 | 3-substituted-4-pyrimidone derivatives | MITSUBISHI PHARMA CORPORATION (JP) | 2008-09-23 | — | — | US | disclosed |