Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 7/20 | 0.54 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.54 |
| ▸ | ABL1 | P00519 | 2/20 | 0.54 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.54 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.54 |
| ▸ | PDE5A | O76074 | 1/20 | 0.52 |
| ▸ | PDE1A | P54750 | 1/20 | 0.52 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.52 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.52 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | ELAVL1 | Q15717 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13913563 | 0.93 | RET (0.62) | RETADORA1ABL1ALKADORA2A | |
| SCHEMBL13913731 | 0.86 | ALDH1A1 (0.62) | RETADORA1ABL1ALKADORA2A | |
| SCHEMBL13913556 | 0.86 | ADORA1 (0.59) | RETADORA1ABL1ALKADORA2A | |
| SCHEMBL13913557 | 0.86 | MEN1 (0.50) | RETADORA1ABL1ALKADORA2A | |
| SCHEMBL13913813 | 0.83 | SIRT1 (0.59) | RETADORA1ABL1ALKADORA2A | |
| SCHEMBL13913562 | 0.83 | ALDH1A1 (0.50) | RETADORA1ABL1ALKADORA2A | |
| SCHEMBL13913680 | 0.83 | PDE5A (0.73) | RETADORA1ABL1ALKADORA2A | |
| SCHEMBL13913560 | 0.82 | ALDH1A1 (0.62) | ADORA1PDE5APDE1APDE1BPDE1C | |
| SCHEMBL13913555 | 0.81 | ADORA1 (0.64) | ADORA1ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL13913624 | 0.81 | RET (0.73) | RETADORA1ABL1ALKADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7504421-B2 | Substituted 2-thio-3,5-dicyano-4-aryl-6-aminopyridines and their use | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2009-03-17 | — | — | US | disclosed |