Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 5/20 | 0.63 |
| ▸ | ADORA1 | P30542 | 10/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.58 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.58 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.58 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.57 |
| ▸ | MAPT | P10636 | 3/20 | 0.57 |
| ▸ | HPGD | P15428 | 3/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.57 |
| ▸ | USP2 | O75604 | 2/20 | 0.57 |
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13914772 | 0.90 | RET (0.69) | RETADORA1ALDH1A1MEN1KMT2A | |
| SCHEMBL13913676 | 0.88 | RET (0.78) | RETADORA1ALDH1A1MEN1KMT2A | |
| SCHEMBL13914654 | 0.87 | RET (0.70) | RETADORA1ALDH1A1MEN1KMT2A | |
| SCHEMBL13914364 | 0.86 | RET (0.68) | RETADORA1ALDH1A1MEN1KMT2A | |
| SCHEMBL13914827 | 0.86 | KDM4E (0.67) | RETADORA1ALDH1A1MEN1KMT2A | |
| SCHEMBL1026394 | 0.84 | ALDH1A1 (0.75) | RETADORA1ALDH1A1MEN1KMT2A | |
| SCHEMBL13913779 | 0.83 | RET (0.71) | RETADORA1ALDH1A1MEN1KMT2A | |
| SCHEMBL13914702 | 0.82 | ADORA1 (0.65) | RETADORA1ALDH1A1MEN1KMT2A | |
| SCHEMBL13914102 | 0.81 | RET (0.71) | RETADORA1ALDH1A1MEN1KMT2A | |
| SCHEMBL13913706 | 0.81 | RET (0.71) | RETADORA1ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7504421-B2 | Substituted 2-thio-3,5-dicyano-4-aryl-6-aminopyridines and their use | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2009-03-17 | — | — | US | disclosed |
| US-7504421-B2 | Substituted 2-thio-3,5-dicyano-4-aryl-6-aminopyridines and their use | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2009-03-17 | — | — | US | disclosed |