Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 1/20 | 0.70 |
| ▸ | ADORA1 | P30542 | 15/20 | 0.65 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.62 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.62 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 4/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.58 |
| ▸ | USP2 | O75604 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13914772 | 0.89 | RET (0.69) | RETADORA1MAPTNPSR1KDM4E | |
| SCHEMBL13914535 | 0.87 | RET (0.63) | RETADORA1ADORA3ADORA2AADORA2B | |
| SCHEMBL13913748 | 0.87 | ADORA1 (0.74) | RETADORA1ADORA3ADORA2AADORA2B | |
| SCHEMBL13914702 | 0.87 | ADORA1 (0.65) | RETADORA1ADORA3ADORA2AADORA2B | |
| SCHEMBL25361247 | 0.85 | ADORA1 (0.72) | RETADORA1ADORA3ADORA2AADORA2B | |
| SCHEMBL13913745 | 0.78 | ADORA1 (1.00) | ADORA1ADORA3ADORA2AADORA2BMAPT | |
| SCHEMBL1026394 | 0.78 | ALDH1A1 (0.75) | RETADORA1ADORA3ADORA2AADORA2B | |
| SCHEMBL13914827 | 0.78 | KDM4E (0.67) | RETADORA1ADORA3ADORA2AMAPT | |
| SCHEMBL19464899 | 0.77 | ADORA1 (1.00) | RETADORA1ADORA3ADORA2AADORA2B | |
| SCHEMBL13914653 | 0.77 | ADORA1 (0.63) | RETADORA1ADORA3ADORA2AADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7504421-B2 | Substituted 2-thio-3,5-dicyano-4-aryl-6-aminopyridines and their use | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2009-03-17 | — | — | US | disclosed |
| US-7504421-B2 | Substituted 2-thio-3,5-dicyano-4-aryl-6-aminopyridines and their use | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2009-03-17 | — | — | US | disclosed |