Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 2/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13919944 | 0.99 | TSHR (0.46) | TSHRHSD17B10ADRA1DADRA1AADRA1B | |
| SCHEMBL13919941 | 0.99 | TSHR (0.46) | TSHRHSD17B10ADRA1DADRA1AADRA1B | |
| SCHEMBL13919948 | 0.90 | ADRA1D (0.41) | TSHRADRA1DADRA1AADRA1BALDH1A1 | |
| SCHEMBL16349637 | 0.90 | NPSR1 (0.54) | TSHRALDH1A1NPSR1CNR1EPHX2 | |
| SCHEMBL13919913 | 0.90 | NPSR1 (0.54) | TSHRALDH1A1NPSR1CNR1EPHX2 | |
| SCHEMBL13919947 | 0.89 | NPSR1 (0.42) | TSHRADRA1DADRA1AADRA1BALDH1A1 | |
| SCHEMBL13919949 | 0.83 | F2 (0.41) | TSHRHSD17B10ALDH1A1HTR4CNR1 | |
| SCHEMBL13919858 | 0.82 | NPSR1 (0.47) | TSHRALDH1A1NPSR1CNR1EPHX2 | |
| SCHEMBL13919671 | 0.82 | HDAC1 (0.48) | ADRA1DADRA1AADRA1BPOLBKDM4E | |
| SCHEMBL15296734 | 0.82 | ALDH1A1 (0.57) | HSD17B10ADRA1DADRA1AADRA1BALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7498405-B2 | Halogen-substituted thienyl compounds | GENESOFT PHARMACEUTICALS, INC. (US) | 2009-03-03 | — | — | US | disclosed |