Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 8/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 8/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.38 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.38 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13920222 | 0.89 | OGA (0.43) | ADORA2AADORA1ADORA3ALDH1A1 | |
| SCHEMBL3156207 | 0.88 | ALDH1A1 (0.48) | ADORA2AADORA1ADORA3SMN1; SMN2ADORA2B | |
| SCHEMBL3162096 | 0.87 | OGA (0.45) | ADORA2AADORA1ALDH1A1 | |
| SCHEMBL3163125 | 0.86 | NPC1 (0.47) | ADORA2AADORA1ADORA3ADORA2BALDH1A1 | |
| SCHEMBL3164709 | 0.86 | NPC1 (0.47) | ADORA2AADORA1ADORA3ADORA2BALDH1A1 | |
| SCHEMBL3163746 | 0.85 | ALDH1A1 (0.50) | ADORA2AADORA1ADORA3SMN1; SMN2ADORA2B | |
| SCHEMBL3165011 | 0.85 | MEN1 (0.46) | ADORA2AADORA1ADORA3SMN1; SMN2ADORA2B | |
| SCHEMBL13920216 | 0.85 | ALDH1A1 (0.47) | SMN1; SMN2ALDH1A1 | |
| SCHEMBL3156611 | 0.85 | MEN1 (0.43) | CHRM2CHRM1CHRM3CACNA1GALDH1A1 | |
| SCHEMBL3162161 | 0.85 | MEN1 (0.46) | ADORA2AADORA1ADORA3CACNA1GADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7501407-B2 | Pyrimidine A2B selective antagonist compounds, their synthesis and use | OSI PHARMACEUTICALS, INC. (US) | 2009-03-10 | — | — | US | disclosed |
| US-7501407-B2 | Pyrimidine A2B selective antagonist compounds, their synthesis and use | OSI PHARMACEUTICALS, INC. (US) | 2009-03-10 | — | — | US | disclosed |