Ammonia Solution, Strong

Ammonia Solution, Strong

SCHEMBL139207

C=CC(=O)NC(CCC)S(=O)(=O)O.N

nearest known ligand 0.42

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 4/20 0.42
ZDHHC20 Q5W0Z9 1/20 0.40
ZDHHC2 Q9UIJ5 1/20 0.40
TAS1R3 Q7RTX0 2/20 0.34
TAS1R1 Q7RTX1 2/20 0.34
HDAC7 Q8WUI4 2/20 0.33
HDAC8 Q9BY41 2/20 0.33
HDAC6 Q9UBN7 2/20 0.33
HDAC9 Q9UKV0 2/20 0.33
HDAC5 Q9UQL6 2/20 0.33
TDP1 Q9NUW8 2/20 0.32
HDAC1 Q13547 2/20 0.32
HDAC2 Q92769 2/20 0.32
ALDH1A1 P00352 1/20 0.32
MAPK1 P28482 1/20 0.32
CHRM1 P11229 1/20 0.32
AKR1A1 P14550 1/20 0.32
CHRM3 P20309 1/20 0.32
HTR2A P28223 1/20 0.32
HTR2C P28335 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21951 0.98 TSHR (0.44) TSHRZDHHC20ZDHHC2TAS1R3TAS1R1
Diethylamine SCHEMBL11696961 0.92 TSHR (0.39) TSHRZDHHC20ZDHHC2TAS1R3TAS1R1
Acrylamide SCHEMBL6055790 0.92 TSHR (0.39) TSHRZDHHC20ZDHHC2TAS1R3TAS1R1
Methacrylic Acid SCHEMBL4180206 0.89 TSHR (0.37) TSHRZDHHC20ZDHHC2TAS1R3TAS1R1
SCHEMBL27662774 0.88 ZDHHC20 (0.46) TSHRZDHHC20ZDHHC2MAPK1TGM2
Crotonic Acid SCHEMBL1001174 0.87 TSHR (0.35) TSHRZDHHC20ZDHHC2TAS1R3TAS1R1
SCHEMBL34026 0.85 TSHR (0.48) TSHRZDHHC20ZDHHC2TDP1ALDH1A1
SCHEMBL28077512 0.85 TSHR (0.48) TSHRZDHHC20ZDHHC2TDP1ALDH1A1
SCHEMBL1634618 0.85 ZDHHC20 (0.51) TSHRZDHHC20ZDHHC2MAPK1TGM2
SCHEMBL29161808 0.85 ZDHHC20 (0.51) TSHRZDHHC20ZDHHC2MAPK1TGM2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20170224604-A1 CATIONIC/CATIONOGENIC COMB COPOLYMER COMPOSITIONS AND PERSONAL CARE PRODUCTS CONTAINING THE SAME EVONIK DEGUSSA GMBH (DE) 2017-08-10 US disclosed
EP-2558510-B1 CATIONIC/CATIONOGENIC COMB COPOLYMER COMPOSITIONS AND PERSONAL CARE PRODUCTS CONTAINING THE SAME AIR PROD & CHEM (US) 2015-05-20 EP disclosed
EP-2558510-A1 CATIONIC/CATIONOGENIC COMB COPOLYMER COMPOSITIONS AND PERSONAL CARE PRODUCTS CONTAINING THE SAME Air Products and Chemicals, Inc. (US) 2013-02-20 EP disclosed
US-20120058060-A1 Cationic/Cationogenic Comb Copolymer Compositions and Personal Care Products Containing the Same AIR PRODUCTS AND CHEMICALS, INC. (US) 2012-03-08 US disclosed
WO-2011130030-A1 CATIONIC/CATIONOGENIC COMB COPOLYMER COMPOSITIONS AND PERSONAL CARE PRODUCTS CONTAINING THE SAME AIR PRODUCTS AND CHEMICALS, INC. (US) 2011-10-20 WO disclosed
EP-0172448-A2 Solid lithium and ammonium salts of poly(acrylamidomethylpropanesulfonic acid) and use thereof to thicken highly polar organic solvents HENKEL CORPORATION (a Delaware corp.) (US) 1986-02-26 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170224604-A1 CATIONIC/CATIONOGENIC COMB COPOLYMER COMPOSITIONS AND PERSONAL CARE PRODUCTS CONTAINING THE SAME C9, CUTA, ZYX TSHR 2653/4885ZDHHC20 698/4885ZDHHC2 1073/4885
US-20120058060-A1 Cationic/Cationogenic Comb Copolymer Compositions and Personal Care Products Containing the Same C9, CUTA, ZYX TSHR 2653/4885ZDHHC20 698/4885ZDHHC2 1073/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.