Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 9/20 | 0.45 |
| ▸ | MAPK12 | P53778 | 9/20 | 0.45 |
| ▸ | MAPK11 | Q15759 | 9/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 9/20 | 0.45 |
| ▸ | MAPT | P10636 | 6/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8241193 | 0.89 | MAPK13 (0.45) | MAPK13MAPK12MAPK11MAPK14MAPT | |
| SCHEMBL935996 | 0.86 | ALDH1A1 (0.50) | MAPK13MAPK12MAPK11MAPK14MAPT | |
| SCHEMBL12657206 | 0.83 | MAPK14 (0.41) | MAPK13MAPK12MAPK11MAPK14MAPT | |
| SCHEMBL2537109 | 0.79 | CHEK1 (0.53) | MAPTALDH1A1LMNAKDM4EL3MBTL1 | |
| SCHEMBL13688636 | 0.79 | MAPT (0.47) | MAPK13MAPK12MAPK11MAPK14MAPT | |
| SCHEMBL13040461 | 0.75 | MAPT (0.41) | MAPK13MAPK12MAPK11MAPK14MAPT | |
| SCHEMBL6857358 | 0.75 | SMN1; SMN2 (0.42) | MAPK13MAPK12MAPK11MAPK14MAPT | |
| SCHEMBL13980288 | 0.74 | CHEK1 (0.38) | MAPK13MAPK12MAPK11MAPK14MAPT | |
| SCHEMBL12227062 | 0.72 | MAPT (0.41) | MAPK13MAPK12MAPK11MAPK14MAPT | |
| SCHEMBL2541882 | 0.72 | MAPT (0.41) | MAPK13MAPK12MAPK11MAPK14MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7498433-B2 | Process and intermediates for the preparation of olanzapine | KRKA, TOVARNA ZDRAVIL, D.D. (SI) | 2009-03-03 | — | — | US | disclosed |