Sugi Predict

Sugi Predict / Compounds / SCHEMBL139223

SCHEMBL139223

SCHEMBL139223

COC(=O)c1ccc(-c2nc(Br)cc(C(=O)OC)c2N)cc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 6/20 0.47
▸ ALDH1A1 P00352 4/20 0.47
▸ KDM4E B2RXH2 4/20 0.47
▸ GAA P10253 2/20 0.47
▸ GLA P06280 1/20 0.47
▸ HPGD P15428 1/20 0.47
▸ CASP1 P29466 1/20 0.47
▸ CASP7 P55210 1/20 0.47
▸ ATM Q13315 1/20 0.47
▸ HSD17B10 Q99714 1/20 0.47
▸ MYC P01106 1/20 0.44
▸ WDR5 P61964 1/20 0.44
▸ MAP2K4 P45985 2/20 0.44
▸ RAB9A P51151 4/20 0.43
▸ SMN1; SMN2 Q16637 2/20 0.43
▸ TP53 P04637 2/20 0.43
▸ MMP2 P08253 1/20 0.43
▸ MMP9 P14780 1/20 0.43
▸ MMP8 P22894 1/20 0.43
▸ MMP13 P45452 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL110366 0.90 PDCD1 (0.47) MAPTALDH1A1KDM4EGAAGLA
SCHEMBL109071 0.89 CA12 (0.42) MAPTALDH1A1KDM4EGAAHPGD
SCHEMBL110319 0.88 MAPT (0.48) MAPTALDH1A1KDM4EMAP2K4RAB9A
SCHEMBL23958640 0.88 LMNA (0.49) MAPTALDH1A1KDM4EGAAHPGD
SCHEMBL110248 0.86 KDM4E (0.42) MAPTALDH1A1KDM4EGAAGLA
SCHEMBL110648 0.84 CA12 (0.47) MAPTALDH1A1KDM4EGAAHPGD
SCHEMBL110162 0.82 KMT2A (0.47) MAPTALDH1A1KDM4EGLAHPGD
SCHEMBL139273 0.82 MKNK1 (0.45) ALDH1A1KDM4EKMT2AMEN1L3MBTL1
SCHEMBL109836 0.82 ALOX5AP (0.40) MAPTALDH1A1KDM4EGAAGLA
SCHEMBL110399 0.80 KMO (0.45) MAPTKDM4EGAAHSD17B10TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8815840-B2 Carbazole and carboline kinase inhibitors BRISTOL-MYERS SQUIBB COMPANY (US) 2014-08-26 — — US disclosed
US-8815840-B2 Carbazole and carboline kinase inhibitors BRISTOL-MYERS SQUIBB COMPANY (US) 2014-08-26 — — US disclosed
EP-2370407-B1 CARBAZOLE AND CARBOLINE KINASE INHIBITORS BRISTOL MYERS SQUIBB CO (US) 2014-06-18 — — EP disclosed
US-20120058988-A1 CARBAZOLE AND CARBOLINE KINASE INHIBITORS BRISTOL-MYERS SQUIBB COMPANY 2012-03-08 — — US disclosed
US-20120058988-A1 CARBAZOLE AND CARBOLINE KINASE INHIBITORS BRISTOL-MYERS SQUIBB COMPANY 2012-03-08 — — US disclosed
CN-102325752-A Carbazole and carboline kinase inhibitors BRISTOL MYERS SQUIBB CO 2012-01-18 — — CN disclosed
EP-2370407-A1 CARBAZOLE AND CARBOLINE KINASE INHIBITORS Bristol-Myers Squibb Company (US) 2011-10-05 — — EP disclosed
WO-2010080474-A1 CARBAZOLE AND CARBOLINE KINASE INHIBITORS BRISTOL-MYERS SQUIBB COMPANY (US) 2010-07-15 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120058988-A1 CARBAZOLE AND CARBOLINE KINASE INHIBITORS JAK2, JAK1, JAK3 MAPT 4508/4885ALDH1A1 1464/4885KDM4E 928/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.