Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 1.00 |
| ▸ | MEN1 | O00255 | 5/20 | 1.00 |
| ▸ | NFKB1 | P19838 | 4/20 | 1.00 |
| ▸ | NFKB2 | Q00653 | 3/20 | 1.00 |
| ▸ | RELA | Q04206 | 3/20 | 1.00 |
| ▸ | AKR1B1 | P15121 | 2/20 | 1.00 |
| ▸ | HSD17B2 | P37059 | 2/20 | 1.00 |
| ▸ | EGFR | P00533 | 1/20 | 1.00 |
| ▸ | SRC | P12931 | 1/20 | 1.00 |
| ▸ | CDK2 | P24941 | 1/20 | 1.00 |
| ▸ | PIK3CA | P42336 | 1/20 | 1.00 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.79 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.79 |
| ▸ | MAPT | P10636 | 4/20 | 0.79 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.79 |
| ▸ | HPGD | P15428 | 3/20 | 0.79 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.79 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.79 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.79 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Butein SCHEMBL29724857 | 1.00 | KMT2A (1.00) | KMT2AMEN1NFKB1NFKB2RELA | |
| Butein SCHEMBL243647 | 1.00 | KMT2A (1.00) | KMT2AMEN1NFKB1NFKB2RELA | |
| Butein SCHEMBL30383523 | 1.00 | KMT2A (1.00) | KMT2AMEN1NFKB1NFKB2RELA | |
| Butein SCHEMBL243646 | 1.00 | KMT2A (1.00) | KMT2AMEN1NFKB1NFKB2RELA | |
| Butein SCHEMBL505501 | 1.00 | KMT2A (1.00) | KMT2AMEN1NFKB1NFKB2RELA | |
| Butein SCHEMBL25202104 | 1.00 | KMT2A (1.00) | KMT2AMEN1NFKB1NFKB2RELA | |
| Butein SCHEMBL25200377 | 0.98 | KMT2A (0.97) | KMT2AMEN1NFKB1NFKB2RELA | |
| SCHEMBL25208375 | 0.90 | MEN1 (0.96) | KMT2AMEN1NFKB1NFKB2RELA | |
| Butein SCHEMBL25209583 | 0.89 | KMT2A (0.80) | KMT2AMEN1NFKB1NFKB2RELA | |
| Butein SCHEMBL1706409 | 0.89 | KMT2A (0.80) | KMT2AMEN1NFKB1NFKB2RELA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 2743 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2026106917-A1 | EDIBLE TRANSMUCOSAL DRUG DELIVERY METHOD USING AN INTERMEDIATE CAPSULE AS A TEMPORARY VESSEL | BioPhysics Pharma, Inc. (US) | 2026-05-21 | — | — | WO | claimed |
| EP-3713561-B1 | COMBINATION OF BUTEIN, ISOLIQUIRITIGENIN AND SULFURETIN, AND ITS USE FOR THE TREATMENT OF DIABETES AND ASSOCIATED DISORDERS | OTAGO INNOVATION LTD (NZ) | 2026-05-06 | — | — | EP | claimed |
| US-12605345-B2 | Transdermal drug delivery system | BioPhysics Pharma, Inc. (US) | 2026-04-21 | — | — | US | claimed |
| EP-4655410-A2 | O-METHYLATION OF PHENOLIC SUBSTANCES VIA FUNGAL O-METHYLTRANSFERASE | Symrise AG (DE) | 2025-12-03 | — | — | EP | claimed |
| EP-4648173-A1 | COMPOSITION FOR ELECTRODE INSULATION COATING, ELECTRODE, AND METHOD FOR MANUFACTURING ELECTRODE | LG Energy Solution, Ltd. (KR) | 2025-11-12 | — | — | EP | claimed |
| US-20250326839-A1 | TREATMENT OF DISEASES RELATED TO COLONY-STIMULATING FACTOR 1 RECEPTOR DYSFUNCTION USING TREM2 AGONISTS | VIGIL NEUROSCIENCE INC (US) | 2025-10-23 | — | — | US | claimed |
| US-20250282866-A1 | TREATMENT OF DISEASES RELATED TO ATP-BINDING CASSETTE TRANSPORTER 1 DYSFUNCTION USING TREM2 AGONISTS | VIGIL NEUROSCIENCE INC (US) | 2025-09-11 | — | — | US | claimed |
| US-20250268841-A1 | Trans-Epithelial Membrane Drug Delivery System | Masiz, John J. (US) | 2025-08-28 | — | — | US | claimed |
| EP-2603098-B1 | METHOD OF IMPROVING STABILITY OF SWEET ENHANCER AND COMPOSITION CONTAINING STABILIZED SWEET ENHANCER | FIRMENICH INCORPORATED (US) | 2025-08-06 | — | — | EP | claimed |
| WO-2025151127-A1 | CHLORELLA AND CORN LEAF EXTRACT COMPOSITIONS, THEIR PRODUCTION, AND METHODS OF USE | UNIGEN, INC. (US) | 2025-07-17 | — | — | WO | claimed |
| US-6221358-B1 | Treating or preventing hangover, alcoholic gastritis and alcohol-induced liver damage; extract contains fustin, fisetin, sulfuretin and butein | FORESTRY RESEARCH INSTITUTE (KR) | 2001-04-24 | — | — | US | claimed |
| WO-1998027970-A2 | TREATMENT OF DISEASES OR PREVENTION OF CELLULAR DAMAGE CAUSED BY OXYGEN-CONTAINING FREE RADICALS | NATIONAL RESEARCH COUNCIL OF CANADA (CA) | 1998-07-02 | — | — | WO | claimed |
| EP-0496349-B1 | Coating solution for preventing adhesion of polymer scale and method for its use | SHINETSU CHEMICAL CO (JP) | 1996-04-10 | — | — | EP | claimed |
| WO-1995006628-A1 | TREATMENT AND PROPHYLAXIS OF DISEASES CAUSED BY PARASITES OR BACTERIA | STATENS SERUMINSTITUT (DK) | 1995-03-09 | — | — | WO | claimed |
| EP-0399051-B1 | POLYVALENT ANTIINFLAMMATORY AGENT | DAINIPPON INK & CHEMICALS (JP) | 1994-05-11 | — | — | EP | claimed |
| US-5234951-A | Anti-ulcer agent comprising chalcone derivative | TSUMURA JUNTENDO, INC. (JP) | 1993-08-10 | — | — | US | claimed |
| EP-0496349-A1 | Coating solution for preventing adhesion of polymer scale and method for its use | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 1992-07-29 | — | — | EP | claimed |
| US-5109025-A | Use of 2',3,4,4'-tetrahydroxychalcone (butein) | DAINIPPON INK AND CHEMICALS, INC. (JP) | 1992-04-28 | — | — | US | claimed |
| EP-0399051-A1 | POLYVALENT ANTIINFLAMMATORY AGENT | DAINIPPON INK AND CHEMICALS, INC. (JP) | 1990-11-28 | — | — | EP | claimed |
| EP-0292576-A1 | ANTI-ULCEROUS AGENT CONTAINING CHALCONE DERIVATIVE AS EFFECTIVE INGREDIENT AND NOVEL CHALCONE DERIVATIVES | TSUMURA & CO. (JP) | 1988-11-30 | — | — | EP | claimed |