Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFE2L2 | Q16236 | 10/20 | 0.45 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.41 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 2/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NQO2 | P16083 | 1/20 | 0.38 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13927700 | 0.82 | NFE2L2 (0.40) | NFE2L2PTGS1PTGS2ALDH1A1NQO2 | |
| SCHEMBL4139751 | 0.81 | NFE2L2 (0.42) | NFE2L2HRH4GRM4RELAPTGS1 | |
| SCHEMBL4139754 | 0.81 | NFE2L2 (0.42) | NFE2L2HRH4GRM4RELAPTGS1 | |
| SCHEMBL13927690 | 0.78 | NFE2L2 (0.45) | NFE2L2HRH4GRM4RELAPTGS1 | |
| SCHEMBL13927756 | 0.74 | NFE2L2 (0.41) | NFE2L2RELAPTGS1PTGS2NPC1 | |
| SCHEMBL14074919 | 0.73 | AURKA (0.49) | ALDH1A1HPGDRAB9ASMN1; SMN2 | |
| SCHEMBL13927755 | 0.71 | ALDH1A1 (0.40) | NFE2L2RELAPTGS1PTGS2KDM4E | |
| SCHEMBL13927661 | 0.68 | NFE2L2 (0.40) | NFE2L2PTGS1PTGS2ALDH1A1NQO2 | |
| SCHEMBL13951020 | 0.68 | CHEK1 (0.47) | NFE2L2GRM4RELAPTGS1PTGS2 | |
| SCHEMBL700536 | 0.67 | NFE2L2 (1.00) | NFE2L2GRM4RELAPTGS1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090054397-A1 | PYRAZOLE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE COMPOUND | OHI NORIHITO | 2009-02-26 | — | — | US | disclosed |
| US-7429609-B2 | Pyrazole compound and medicinal composition containing the same | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2008-09-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090054397-A1 | PYRAZOLE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE COMPOUND | CNKSR1, NR3C2, CSNK2B | NFE2L2 434/4885HRH4 248/4885GRM4 1775/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.