Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 7/20 | 0.63 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | BRD4 | O60885 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4474701 | 0.91 | KCNH2 (0.62) | KCNH2POLBMAPK1SMN1; SMN2KMT2A | |
| SCHEMBL4475502 | 0.89 | KCNH2 (0.60) | KCNH2POLBMAPK1SMN1; SMN2KMT2A | |
| SCHEMBL4459637 | 0.89 | KCNH2 (0.60) | KCNH2POLBMAPK1SMN1; SMN2KMT2A | |
| SCHEMBL4456998 | 0.89 | KCNH2 (0.60) | KCNH2POLBMAPK1SMN1; SMN2KMT2A | |
| SCHEMBL13932375 | 0.87 | KCNH2 (0.64) | KCNH2 | |
| SCHEMBL5634360 | 0.80 | KCNH2 (0.72) | KCNH2 | |
| SCHEMBL5634365 | 0.79 | KCNH2 (0.52) | KCNH2POLBMAPK1SMN1; SMN2KMT2A | |
| SCHEMBL4472864 | 0.79 | KCNH2 (0.63) | KCNH2 | |
| SCHEMBL4464147 | 0.78 | SLC6A3 (0.58) | POLBSMN1; SMN2 | |
| SCHEMBL5632884 | 0.78 | KCNH2 (0.81) | KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7511077-B2 | Diamine calcium channel blockers | NEUROMED PHARMACEUTICALS LTD. (CA) | 2009-03-31 | — | — | US | disclosed |