⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9167025 | 1.00 | POLB (0.60) | — | |
| SCHEMBL9172023 | 1.00 | POLB (0.60) | — | |
| SCHEMBL9168067 | 0.97 | POLB (0.58) | — | |
| Hydrochloric Acid SCHEMBL2009370 | 0.97 | SMN1; SMN2 (0.58) | — | |
| Hydrochloric Acid SCHEMBL960566 | 0.97 | SMN1; SMN2 (0.58) | — | |
| SCHEMBL9172017 | 0.95 | POLB (0.56) | — | |
| SCHEMBL6537798 | 0.91 | POLB (0.52) | — | |
| Trifluoroacetic Acid SCHEMBL4504873 | 0.81 | POLB (0.43) | — | |
| SCHEMBL13779204 | 0.80 | — | — | |
| SCHEMBL7137154 | 0.80 | ALDH1A1 (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 186 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119707838-A | Synthesis method of (S) -2-piperazinylacetonitrile or salt thereof | 杭州澳赛诺生物科技有限公司 | 2025-03-28 | — | — | CN | claimed |
| CN-116854641-A | Preparation method of 2-piperazine acetonitrile derivative and 2-piperazine acetonitrile | 重庆博腾制药科技股份有限公司 | 2023-10-10 | — | — | CN | claimed |
| CN-116855568-A | Preparation of (S) -2-piperazine acetonitrile and hydrochloride thereof by enzyme resolution method | 重庆博腾制药科技股份有限公司 | 2023-10-10 | — | — | CN | claimed |
| CN-116854642-A | Preparation method of (S) -2-piperazine acetonitrile and hydrochloride thereof | 重庆博腾制药科技股份有限公司 | 2023-10-10 | — | — | CN | claimed |
| CN-116120243-A | aPKC inhibitor compound intermediate fragment, preparation method and application thereof | 都创(上海)医药科技股份有限公司 | 2023-05-16 | — | — | CN | claimed |
| CN-101484420-A | Indoles as 5-HT 6 modulators | BIOVITRUM AB PUBL (SE) | 2009-07-15 | — | — | CN | claimed |
| EP-4029868-B1 | MCL-1 INHIBITORS | GILEAD SCIENCES INC (US) | 2026-05-20 | — | — | EP | disclosed |
| CN-119707838-B | Synthesis method of (S) -2-piperazinylacetonitrile or salt thereof | 杭州澳赛诺生物科技有限公司 | 2025-10-17 | — | — | CN | disclosed |
| CN-119707838-B | Synthesis method of (S) -2-piperazinylacetonitrile or salt thereof | 杭州澳赛诺生物科技有限公司 | 2025-10-17 | — | — | CN | disclosed |
| CN-119707838-A | Synthesis method of (S) -2-piperazinylacetonitrile or salt thereof | 杭州澳赛诺生物科技有限公司 | 2025-03-28 | — | — | CN | disclosed |
| CN-119707838-A | Synthesis method of (S) -2-piperazinylacetonitrile or salt thereof | 杭州澳赛诺生物科技有限公司 | 2025-03-28 | — | — | CN | disclosed |
| CN-119707838-A | Synthesis method of (S) -2-piperazinylacetonitrile or salt thereof | 杭州澳赛诺生物科技有限公司 | 2025-03-28 | — | — | CN | disclosed |
| CN-119039289-A | Novel intermediate for synthesis of adaGesibirica and preparation method thereof | 安庆多辉生物科技有限公司 | 2024-11-29 | — | — | CN | disclosed |
| EP-0832887-B1 | N-acylpiperazine derivative, anti-ulcer drug, and antibacterial drug | SHISEIDO CO LTD (JP) | 2001-08-08 | — | — | EP | disclosed |
| WO-2001007436-A2 | SUBSTITUTED OXOAZAHETEROCYCLYL COMPOUNDS | AVENTIS PHARMACEUTICALS INC. (US) | 2001-02-01 | — | — | WO | disclosed |
| US-5962456-A | PEPTIC ULCERS | SHISEIDO CO., LTD. (JP) | 1999-10-05 | — | — | US | disclosed |
| EP-0832887-A1 | N-acylpiperazine derivative, anti-ulcer drug, and antibacterial drug | SHISEIDO COMPANY LIMITED (JP) | 1998-04-01 | — | — | EP | disclosed |
| CN-1163612-A | Preparation of immunogens and other conjugates of drugs | DADE CHEMISTRY SYSTEMS INC (US) | 1997-10-29 | — | — | CN | disclosed |
| CN-1134422-A | Improved process for large-scale production of BMS 180048 and analogs | BRISTOL MYERS SQUIBB CO (US) | 1996-10-30 | — | — | CN | disclosed |
| US-3925389-A | Preparation of aminoethylpiperazines | TEXACO INC. | 1975-12-09 | — | — | US | disclosed |