Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.30 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.30 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.30 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.30 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2576487 | 1.00 | ALDH1A1 (0.50) | ALDH1A1PKMPOLBLMNAMAPT | |
| SCHEMBL11701515 | 1.00 | — | — | |
| SCHEMBL22691920 | 0.91 | POLB (0.56) | ALDH1A1PKMPOLBLMNAMAPT | |
| SCHEMBL11501758 | 0.91 | ALDH1A1 (0.57) | ALDH1A1PKMPOLBLMNAMAPT | |
| SCHEMBL18000680 | 0.87 | — | — | |
| SCHEMBL15370642 | 0.87 | ALDH1A1 (0.46) | ALDH1A1PKMPOLBLMNAMAPT | |
| SCHEMBL64890 | 0.87 | — | — | |
| SCHEMBL16097879 | 0.87 | — | — | |
| SCHEMBL3230975 | 0.86 | ALDH1A1 (0.40) | ALDH1A1PKMPOLBLMNA | |
| SCHEMBL1307806 | 0.86 | ALDH1A1 (0.40) | ALDH1A1PKMPOLBLMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1015419-B1 | POLYDENTATE IMINES AND THEIR METAL COMPLEXES | AMERSHAM PLC (GB) | 2003-01-02 | — | — | EP | disclosed |
| US-6153775-A | TRIPODAL LIGAND CHELATING AGENTS INCORPORATING IMINE BONDS AND WHICH FORM COMPLEXES THAT DO NOT HYDROLYZE IN WATER AT NEUTRAL PH; CONTRAST AGENTS FOR MAGNETIC RESONANCE IMAGING/RADIOLOGY | NYCOMED AMERSHAM PLC. (GB) | 2000-11-28 | — | — | US | disclosed |