Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | TLR2 | O60603 | 4/20 | 0.53 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.47 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.46 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16592017 | 0.96 | KMT2A (0.58) | KMT2ATLR2MDM2TPSAB1 | |
| SCHEMBL13328283 | 0.92 | TLR2 (0.53) | KMT2ATLR2MDM2TLR1 | |
| SCHEMBL17002047 | 0.92 | MDM2 (0.51) | KMT2ATLR2MDM2TLR1 | |
| SCHEMBL10078346 | 0.89 | KMT2A (0.50) | KMT2ATLR2MDM2 | |
| SCHEMBL16093051 | 0.89 | KMT2A (0.50) | KMT2ATLR2MDM2 | |
| SCHEMBL12971617 | 0.89 | KMT2A (0.61) | KMT2ATLR2MDM2 | |
| SCHEMBL13311876 | 0.89 | TLR2 (0.61) | TLR2MDM2 | |
| SCHEMBL12019008 | 0.89 | TLR2 (0.49) | KMT2ATLR2MDM2TPSAB1 | |
| SCHEMBL13319576 | 0.89 | TLR2 (0.49) | KMT2ATLR2MDM2TPSAB1 | |
| SCHEMBL19919108 | 0.89 | TLR2 (0.64) | KMT2ATLR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7479495-B2 | N-heterocyclic inhibitors of TNF-α expression | PHARMACOPEIA, INC. (US) | 2009-01-20 | — | — | US | disclosed |