Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 5/20 | 0.67 |
| ▸ | CALML3 | P27482 | 7/20 | 0.63 |
| ▸ | MAOB | P27338 | 2/20 | 0.63 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.63 |
| ▸ | SDHA | P31040 | 2/20 | 0.63 |
| ▸ | LMNA | P02545 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10197443 | 1.00 | MAOA (0.67) | MAOACALML3MAOBPTGS1SDHA | |
| SCHEMBL11983108 | 0.93 | MAOA (0.66) | MAOACALML3MAOBPTGS1SDHA | |
| SCHEMBL14432626 | 0.93 | MAOA (0.66) | MAOACALML3MAOBPTGS1SDHA | |
| SCHEMBL19938053 | 0.93 | MAOA (0.66) | MAOACALML3MAOBPTGS1SDHA | |
| SCHEMBL10197320 | 0.92 | MAOA (0.65) | MAOACALML3MAOBPTGS1SDHA | |
| SCHEMBL13148658 | 0.92 | MAOA (0.65) | MAOACALML3MAOBPTGS1SDHA | |
| SCHEMBL4816294 | 0.92 | MAOA (0.65) | MAOACALML3MAOBPTGS1SDHA | |
| SCHEMBL10197257 | 0.92 | MAOA (0.65) | MAOACALML3MAOBPTGS1SDHA | |
| SCHEMBL3088861 | 0.92 | MAOA (0.65) | MAOACALML3MAOBPTGS1SDHA | |
| SCHEMBL1394150 | 0.92 | MAOA (0.65) | MAOACALML3MAOBPTGS1SDHA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115536783-A | Solvent-free, acrylic hybrid polyurethane resins, methods of making, compositions containing, and methods of making and using | 广州秀珀化工涂料有限公司 | 2022-12-30 | — | — | CN | disclosed |
| US-9550783-B2 | Biaryl heterocyclic compounds and methods of making and using the same | MELINTA THERAPEUTICS, INC. (US) | 2017-01-24 | — | — | US | disclosed |
| US-20150072970-A1 | BIARYL HETEROCYCLIC COMPOUNDS AND METHODS OF MAKING AND USING THE SAME | MELINTA THERAPEUTICS, INC. (US) | 2015-03-12 | — | — | US | disclosed |
| US-20140073624-A1 | Biaryl Heterocyclic Compounds and Methods of Making and Using the Same | RIB-X PHARMACEUTICALS, INC. (US) | 2014-03-13 | — | — | US | disclosed |
| US-8362300-B2 | Addition compounds suitable as dispersants and dispersion stabilizers | BYK-CHEMIE GMBH (DE) | 2013-01-29 | — | — | US | disclosed |
| EP-2492264-A2 | Biaryl Heterocyclic Compounds And Methods Of Making And Using The Same | Rib-X Pharmaceuticals, Inc. (US) | 2012-08-29 | — | — | EP | disclosed |
| EP-1656370-B1 | BIARYL HETEROCYCLIC COMPOUNDS AND METHODS OF MAKING AND USING THE SAME | RIB X PHARMACEUTICALS INC (US) | 2012-08-15 | — | — | EP | disclosed |
| US-20120010200-A1 | Biaryl Heterocyclic Compounds And Methods Of Making And Using The Same | RIB-X PHARMACEUTICALS, INC. | 2012-01-12 | — | — | US | disclosed |
| US-20100234591-A1 | BIARYL HETEROCYCLIC COMPOUNDS AND METHODS OF MAKING AND USING THE SAME | RIB-X PHARMACEUTICALS, INC. (US) | 2010-09-16 | — | — | US | disclosed |
| US-7705026-B2 | Biaryl heterocyclic compounds and methods of making and using the same | RIB-X PHARMACEUTICALS, INC. (US) | 2010-04-27 | — | — | US | disclosed |
| US-20050250927-A1 | Addition compounds suitable as dispersants and dispersion stabilizers | BYK-CHEMIE GMBH | 2005-11-10 | — | — | US | disclosed |
| US-20050203147-A1 | Biaryl heterocyclic compounds and methods of making and using the same | MELINTA SUBSIDIARY CORP. | 2005-09-15 | — | — | US | disclosed |
| WO-2005070904-A2 | SULFONAMIDE COMPOUNDS AND METHODS OF MAKING AND USING THE SAME | RIB-X PHARMACEUTICAL, INC. (US) | 2005-08-04 | — | — | WO | disclosed |
| US-20050153971-A1 | Halogenated biaryl heterocyclic compounds and methods of making and using the same | MELINTA SUBSIDIARY CORP. | 2005-07-14 | — | — | US | disclosed |
| WO-2005061468-A1 | HALOGENATED BIARYL HETEROCYCLIC COMPOUNDS AND METHODS OF MAKING AND USING THE SAME | RIB-X PHARMACEUTICALS, INC. (US) | 2005-07-07 | — | — | WO | disclosed |
| WO-2005019211-A2 | BIARYL HETEROCYCLIC COMPOUNDS AND METHODS OF MAKING AND USING THE SAME | RIB-X PHARMACEUTICALS, INC. (US) | 2005-03-03 | — | — | WO | disclosed |
| US-20050043317-A1 | Biaryl heterocyclic compounds and methods of making and using the same | MELINTA SUBSIDIARY CORP. | 2005-02-24 | — | — | US | disclosed |
| WO-2005012270-A2 | BIARYL HETEROCYCLIC AMINES, AMIDES, AND SULFUR-CONTAINING COMPOUNDS AND METHODS OF MAKING AND USING THE SAME | RIB-X PHARMACEUTICALS, INC. (US) | 2005-02-10 | — | — | WO | disclosed |
| EP-1497257-A1 | 2,5-BIS-DIAMINE-[1,4] BENZOQUINONE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE, A PROCESS FOR THEIR PREPARATION AND INTERMEDIATES THEREFOR | Alma Mater Studiorum -Universita' di Bologna (IT) | 2005-01-19 | — | — | EP | disclosed |
| WO-2003087035-A1 | 2,5-BIS-DIAMINE-'1,4! BENZOQUINONE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE A PROCESS FOR THEIR PREPARATION AND INTERMEDIATES THEREFOR | ALMA MATER STUDIORUM-UNIVERSITA' DI BOLOGNA (IT) | 2003-10-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050153971-A1 | Halogenated biaryl heterocyclic compounds and methods of making and using the same | PROKR1, PROKR2, PCNA | MAOA 1365/4885CALML3 4062/4885MAOB 1682/4885 |
| US-20100234591-A1 | BIARYL HETEROCYCLIC COMPOUNDS AND METHODS OF MAKING AND USING THE SAME | PCNA, AADAC, MIF | MAOA 872/4885CALML3 3842/4885MAOB 994/4885 |
| US-20150072970-A1 | BIARYL HETEROCYCLIC COMPOUNDS AND METHODS OF MAKING AND USING THE SAME | PCNA, AADAC, MIF | MAOA 872/4885CALML3 3842/4885MAOB 994/4885 |
| US-20050043317-A1 | Biaryl heterocyclic compounds and methods of making and using the same | PCNA, AADAC, MIF | MAOA 872/4885CALML3 3842/4885MAOB 994/4885 |
| US-20120010200-A1 | Biaryl Heterocyclic Compounds And Methods Of Making And Using The Same | PCNA, AADAC, MIF | MAOA 872/4885CALML3 3842/4885MAOB 994/4885 |
| US-20140073624-A1 | Biaryl Heterocyclic Compounds and Methods of Making and Using the Same | PCNA, AADAC, MIF | MAOA 872/4885CALML3 3842/4885MAOB 994/4885 |
| US-20050203147-A1 | Biaryl heterocyclic compounds and methods of making and using the same | PCNA, AADAC, MIF | MAOA 872/4885CALML3 3842/4885MAOB 994/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.