Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 9/20 | 0.43 |
| ▸ | LTA4H | P09960 | 5/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ACE2 | Q9BYF1 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12253518 | 0.80 | ACE (0.52) | ACELTA4HLMNAACE2SMN1; SMN2 | |
| SCHEMBL13923719 | 0.74 | ACE (0.63) | ACELTA4HTSHRLMNAACE2 | |
| SCHEMBL7145133 | 0.69 | ACE (0.60) | ACELTA4HACE2 | |
| SCHEMBL6979678 | 0.67 | LTA4H (0.63) | ACELTA4HACE2 | |
| SCHEMBL6973372 | 0.67 | LTA4H (0.63) | ACELTA4HACE2 | |
| SCHEMBL6979674 | 0.67 | LTA4H (0.63) | ACELTA4HACE2 | |
| SCHEMBL9245561 | 0.66 | ACE (0.59) | ACELTA4HLMNAACE2 | |
| SCHEMBL10863223 | 0.66 | ACE (0.49) | ACELTA4HLMNAACE2 | |
| SCHEMBL11565565 | 0.66 | ACE (0.66) | ACELTA4HACE2 | |
| SCHEMBL9554742 | 0.66 | ACE (0.81) | ACELTA4HACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7485630-B2 | Neuroprotective macrocyclic compounds and methods for their use | NEUREN PHARMACEUTICALS LIMITED (NZ) | 2009-02-03 | — | — | US | disclosed |