Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 4/20 | 0.80 |
| ▸ | SHMT2 | P34897 | 2/20 | 0.77 |
| ▸ | BCDIN3D | Q7Z5W3 | 6/20 | 0.60 |
| ▸ | MEN1 | O00255 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13943729 | 0.90 | HTR2C (0.98) | HTR2CSHMT2BCDIN3DMEN1KMT2A | |
| SCHEMBL13942962 | 0.90 | HTR2C (0.82) | HTR2CSHMT2BCDIN3DMEN1KMT2A | |
| SCHEMBL13943727 | 0.89 | HTR2C (1.00) | HTR2CSHMT2BCDIN3DMEN1KMT2A | |
| SCHEMBL13943713 | 0.87 | KMT2A (0.74) | HTR2CSHMT2BCDIN3DMEN1KMT2A | |
| SCHEMBL13944738 | 0.87 | SHMT2 (1.00) | HTR2CSHMT2BCDIN3DMEN1KMT2A | |
| SCHEMBL13944735 | 0.86 | SHMT2 (0.98) | HTR2CSHMT2BCDIN3DMEN1KMT2A | |
| SCHEMBL13943259 | 0.85 | HTR2C (0.74) | HTR2CSHMT2BCDIN3DMEN1KMT2A | |
| SCHEMBL13944352 | 0.84 | HTR2C (0.59) | HTR2CSHMT2BCDIN3DMEN1KMT2A | |
| SCHEMBL13944197 | 0.84 | HTR2C (0.61) | HTR2CSHMT2BCDIN3DMEN1KMT2A | |
| SCHEMBL13944370 | 0.84 | PDE2A (0.65) | HTR2CSHMT2BCDIN3D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009023978-A1 | PYRAZOLO [3,4 -D] PYRIMIDINE COMPOUNDS AND THEIR USE AS MODULATORS OF PROTEIN KINASE | ONCALIS AG (CH) | 2009-02-26 | — | — | WO | disclosed |
| EP-2025678-A1 | Pyrazolo[3,4-d]pyrimidine compounds and their use as modulators of protein kinase | Oncalis AG (CH) | 2009-02-18 | — | — | EP | disclosed |