Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 3/20 | 0.65 |
| ▸ | BCDIN3D | Q7Z5W3 | 12/20 | 0.61 |
| ▸ | PLK4 | O00444 | 2/20 | 0.58 |
| ▸ | HTR2C | P28335 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13943258 | 0.91 | BCDIN3D (0.59) | PDE2ABCDIN3DPLK4HTR2CSHMT2 | |
| SCHEMBL23579680 | 0.84 | HTR2C (0.55) | PDE2ABCDIN3DHTR2CSHMT2 | |
| SCHEMBL13942971 | 0.84 | HTR2C (0.80) | BCDIN3DHTR2CSHMT2 | |
| SCHEMBL13947561 | 0.83 | PDE2A (0.76) | PDE2ABCDIN3DPLK4TP53 | |
| SCHEMBL23579870 | 0.81 | BCDIN3D (0.52) | PDE2ABCDIN3DHTR2CSHMT2 | |
| SCHEMBL13943748 | 0.80 | TP53 (0.61) | PDE2ABCDIN3DHTR2CTP53SHMT2 | |
| SCHEMBL13947033 | 0.78 | PDE2A (0.67) | PDE2ABCDIN3DPLK4TP53SHMT2 | |
| SCHEMBL13947571 | 0.78 | PDE2A (0.67) | PDE2ABCDIN3DPLK4TP53 | |
| SCHEMBL13944197 | 0.78 | HTR2C (0.61) | BCDIN3DPLK4HTR2CTP53SHMT2 | |
| SCHEMBL13947566 | 0.77 | PDE2A (0.62) | PDE2ABCDIN3DPLK4TP53SHMT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009023978-A1 | PYRAZOLO [3,4 -D] PYRIMIDINE COMPOUNDS AND THEIR USE AS MODULATORS OF PROTEIN KINASE | ONCALIS AG (CH) | 2009-02-26 | — | — | WO | disclosed |
| EP-2025678-A1 | Pyrazolo[3,4-d]pyrimidine compounds and their use as modulators of protein kinase | Oncalis AG (CH) | 2009-02-18 | — | — | EP | disclosed |