Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 4/20 | 0.63 |
| ▸ | HTR2C | P28335 | 6/20 | 0.62 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.61 |
| ▸ | CDK2 | P24941 | 3/20 | 0.61 |
| ▸ | BCDIN3D | Q7Z5W3 | 2/20 | 0.61 |
| ▸ | PDE5A | O76074 | 1/20 | 0.53 |
| ▸ | HRH1 | P35367 | 1/20 | 0.52 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.52 |
| ▸ | PDE2A | O00408 | 1/20 | 0.51 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13947039 | 0.93 | BCDIN3D (0.62) | HRH4HTR2CCCNE1CDK2BCDIN3D | |
| SCHEMBL13943315 | 0.90 | PIK3CA (0.63) | HRH4HTR2CCCNE1CDK2BCDIN3D | |
| SCHEMBL13947132 | 0.88 | HTR2C (0.59) | HRH4HTR2CPDE5AHRH1PDE2A | |
| SCHEMBL13944729 | 0.87 | HTR2C (0.72) | HRH4HTR2CPDE5APDE2A | |
| SCHEMBL13946820 | 0.87 | HTR2C (0.70) | HRH4HTR2CPDE5AHRH1PDE2A | |
| SCHEMBL23579669 | 0.83 | HTR2C (0.53) | HRH4HTR2CBCDIN3DPDE5AHRH1 | |
| SCHEMBL30034965 | 0.83 | HTR2C (0.53) | HRH4HTR2CBCDIN3DPDE5AHRH1 | |
| SCHEMBL13946800 | 0.82 | HTR2C (0.60) | HRH4HTR2CBCDIN3DPDE5APIK3CA | |
| SCHEMBL13943714 | 0.80 | HTR2C (0.58) | HRH4HTR2CBCDIN3DPDE5AHRH1 | |
| SCHEMBL13943266 | 0.80 | HTR2C (0.58) | HRH4HTR2CBCDIN3DHRH1PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009023978-A1 | PYRAZOLO [3,4 -D] PYRIMIDINE COMPOUNDS AND THEIR USE AS MODULATORS OF PROTEIN KINASE | ONCALIS AG (CH) | 2009-02-26 | — | — | WO | disclosed |