Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCDIN3D | Q7Z5W3 | 2/20 | 0.62 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.60 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.59 |
| ▸ | CDK2 | P24941 | 4/20 | 0.59 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.59 |
| ▸ | HTR2C | P28335 | 4/20 | 0.56 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.54 |
| ▸ | PDE2A | O00408 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13944362 | 0.93 | HRH4 (0.63) | BCDIN3DPIK3CACCNE1CDK2CCNE2 | |
| SCHEMBL13943315 | 0.91 | PIK3CA (0.63) | BCDIN3DPIK3CACCNE1CDK2CCNE2 | |
| SCHEMBL13943266 | 0.87 | HTR2C (0.58) | BCDIN3DPIK3CAHTR2CHRH4PDE2A | |
| SCHEMBL3644693 | 0.87 | HTR2C (0.58) | BCDIN3DPIK3CAHTR2CHRH4PDE2A | |
| SCHEMBL13944731 | 0.86 | HTR2C (0.72) | PIK3CAHTR2CHRH4PDE2A | |
| SCHEMBL13944350 | 0.86 | PDE2A (0.68) | BCDIN3DPIK3CAHTR2CHRH4PDE2A | |
| SCHEMBL23579785 | 0.82 | HTR2C (0.53) | BCDIN3DPIK3CAHTR2CHRH4PDE2A | |
| SCHEMBL30033897 | 0.82 | HTR2C (0.53) | BCDIN3DPIK3CAHTR2CHRH4PDE2A | |
| SCHEMBL13944374 | 0.81 | PIK3CA (0.58) | BCDIN3DPIK3CAHTR2CPDE2ALMNA | |
| SCHEMBL13947132 | 0.81 | HTR2C (0.59) | HTR2CHRH4PDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2025678-A1 | Pyrazolo[3,4-d]pyrimidine compounds and their use as modulators of protein kinase | Oncalis AG (CH) | 2009-02-18 | — | — | EP | disclosed |