Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 9/20 | 0.60 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.50 |
| ▸ | PDE2A | O00408 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | HTR6 | P50406 | 1/20 | 0.48 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.48 |
| ▸ | PDE5A | O76074 | 1/20 | 0.48 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.48 |
| ▸ | BCDIN3D | Q7Z5W3 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13944374 | 0.93 | PIK3CA (0.58) | HTR2CPIK3CAPDE2AKDM4EBCDIN3D | |
| SCHEMBL13947036 | 0.92 | PIK3CA (0.60) | HTR2CPIK3CAPDE2AKDM4EBCDIN3D | |
| SCHEMBL13944357 | 0.90 | PIK3CA (0.61) | HTR2CPIK3CAPDE2AKDM4EPDE5A | |
| SCHEMBL13942977 | 0.86 | PDE2A (0.69) | HTR2CPDE2AHTR6ATAD2PDE5A | |
| SCHEMBL13946820 | 0.83 | HTR2C (0.70) | HTR2CPDE2AHTR6ATAD2PDE5A | |
| SCHEMBL13944362 | 0.82 | HRH4 (0.63) | HTR2CPIK3CAPDE2APDE5AHRH4 | |
| SCHEMBL13947032 | 0.79 | BCDIN3D (0.61) | HTR2CPDE2AKDM4EBCDIN3DTP53 | |
| SCHEMBL13944729 | 0.79 | HTR2C (0.72) | HTR2CPDE2APDE5AHRH4TP53 | |
| SCHEMBL13943321 | 0.79 | TP53 (0.65) | HTR2CPIK3CAPDE2AHRH4BCDIN3D | |
| SCHEMBL13947132 | 0.78 | HTR2C (0.59) | HTR2CPDE2APDE5AHRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2025678-A1 | Pyrazolo[3,4-d]pyrimidine compounds and their use as modulators of protein kinase | Oncalis AG (CH) | 2009-02-18 | — | — | EP | disclosed |