Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 3/20 | 0.40 |
| ▸ | HTR3A | P46098 | 1/20 | 0.40 |
| ▸ | PAK1 | Q13153 | 4/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | TYK2 | P29597 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 7/20 | 0.36 |
| ▸ | WNT1 | P04628 | 3/20 | 0.36 |
| ▸ | CLK2 | P49760 | 1/20 | 0.36 |
| ▸ | CLK3 | P49761 | 1/20 | 0.36 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 2/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13923940 | 0.79 | HAO1 (0.41) | CHRNA7HTR3APAK1JAK2JAK1 | |
| SCHEMBL13923946 | 0.79 | HAO1 (0.41) | CHRNA7HTR3APAK1JAK2JAK1 | |
| SCHEMBL13923941 | 0.79 | HAO1 (0.41) | CHRNA7HTR3APAK1JAK2JAK1 | |
| SCHEMBL2086463 | 0.77 | CHRNA7 (0.61) | CHRNA7HTR3AUSP30NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL2085876 | 0.76 | CHRNA7 (0.60) | CHRNA7HTR3AUSP30NPC1RAB9A | |
| SCHEMBL13923944 | 0.68 | CHRNA7 (0.41) | CHRNA7HTR3ADYRK1AWNT1CLK2 | |
| SCHEMBL13923943 | 0.68 | CHRNA7 (0.41) | CHRNA7HTR3ADYRK1AWNT1CLK2 | |
| SCHEMBL13923945 | 0.68 | CHRNA7 (0.41) | CHRNA7HTR3ADYRK1AWNT1CLK2 | |
| SCHEMBL4604965 | 0.67 | CHRNA7 (0.62) | CHRNA7HTR3ADYRK1AWNT1USP30 | |
| SCHEMBL4605684 | 0.67 | CHRNA7 (0.62) | CHRNA7HTR3ADYRK1AWNT1USP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7488737-B2 | Indoles, 1H-indazoles, 1,2-benzisoxazoles, 1,2-benzoisothiazoles, and preparation and uses thereof | MEMORY PHARMACEUTICAL CORPORATION (US) | 2009-02-10 | — | — | US | disclosed |