Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 5/20 | 0.59 |
| ▸ | CALML3 | P27482 | 6/20 | 0.58 |
| ▸ | MAOB | P27338 | 2/20 | 0.58 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.58 |
| ▸ | SDHA | P31040 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5173460 | 0.91 | MAOA (0.58) | MAOACALML3MAOBPTGS1SDHA | |
| SCHEMBL5173454 | 0.91 | MAOA (0.58) | MAOACALML3MAOBPTGS1SDHA | |
| SCHEMBL10266866 | 0.89 | MAOA (0.64) | MAOACALML3MAOBPTGS1SDHA | |
| SCHEMBL5173464 | 0.88 | MAOA (0.57) | MAOACALML3MAOBPTGS1SDHA | |
| SCHEMBL4573648 | 0.87 | MAOA (0.64) | MAOACALML3MAOBPTGS1SDHA | |
| SCHEMBL4573653 | 0.87 | MAOA (0.64) | MAOACALML3MAOBPTGS1SDHA | |
| SCHEMBL10259146 | 0.86 | MAOA (0.63) | MAOACALML3MAOBPTGS1SDHA | |
| SCHEMBL11983108 | 0.85 | MAOA (0.66) | MAOACALML3MAOBPTGS1SDHA | |
| SCHEMBL19938053 | 0.85 | MAOA (0.66) | MAOACALML3MAOBPTGS1SDHA | |
| SCHEMBL14432500 | 0.85 | MAOA (0.59) | MAOACALML3MAOBPTGS1SDHA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018185650-A1 | POLYURETHANE COMPOSITE | UNIVERSIDAD DE ANTIOQUIA (CO) | 2018-10-11 | — | — | WO | claimed |
| WO-1999026993-A1 | POLYURETHANE CRYSTALLINE THERMOPLASTIC AND METHOD FOR THE PRODUCTION THEREOF | MERQUINSA MERCADOS QUIMICOS S.L. (ES) | 1999-06-03 | — | — | WO | claimed |
| WO-1998056844-A1 | POLYURETHANE THERMOPLASTIC MATERIAL AND PRODUCTION PROCESS | MERQUINSA MERCADOS QUIMICOS, S.L. (ES) | 1998-12-17 | — | — | WO | claimed |
| WO-2018185650-A1 | POLYURETHANE COMPOSITE | UNIVERSIDAD DE ANTIOQUIA (CO) | 2018-10-11 | — | — | WO | disclosed |
| US-9550783-B2 | Biaryl heterocyclic compounds and methods of making and using the same | MELINTA THERAPEUTICS, INC. (US) | 2017-01-24 | — | — | US | disclosed |
| US-20150072970-A1 | BIARYL HETEROCYCLIC COMPOUNDS AND METHODS OF MAKING AND USING THE SAME | MELINTA THERAPEUTICS, INC. (US) | 2015-03-12 | — | — | US | disclosed |
| US-20140073624-A1 | Biaryl Heterocyclic Compounds and Methods of Making and Using the Same | RIB-X PHARMACEUTICALS, INC. (US) | 2014-03-13 | — | — | US | disclosed |
| EP-2492264-A2 | Biaryl Heterocyclic Compounds And Methods Of Making And Using The Same | Rib-X Pharmaceuticals, Inc. (US) | 2012-08-29 | — | — | EP | disclosed |
| EP-1656370-B1 | BIARYL HETEROCYCLIC COMPOUNDS AND METHODS OF MAKING AND USING THE SAME | RIB X PHARMACEUTICALS INC (US) | 2012-08-15 | — | — | EP | disclosed |
| US-20120010200-A1 | Biaryl Heterocyclic Compounds And Methods Of Making And Using The Same | RIB-X PHARMACEUTICALS, INC. | 2012-01-12 | — | — | US | disclosed |
| US-20100234591-A1 | BIARYL HETEROCYCLIC COMPOUNDS AND METHODS OF MAKING AND USING THE SAME | RIB-X PHARMACEUTICALS, INC. (US) | 2010-09-16 | — | — | US | disclosed |
| US-7456206-B2 | Biaryl heterocyclic compounds and methods of making and using the same | RIB-X PHARMACEUTICALS, INC. (US) | 2008-11-25 | — | — | US | disclosed |
| US-7148219-B2 | Biaryl heterocyclic compounds and methods of making and using the same | RIB-X PHARMACEUTICALS, INC. (US) | 2006-12-12 | — | — | US | disclosed |
| US-20060264426-A1 | Biaryl heterocyclic compounds and methods of making and using the same | MELINTA SUBSIDIARY CORP. | 2006-11-23 | — | — | US | disclosed |
| EP-1656370-A2 | BIARYL HETEROCYCLIC COMPOUNDS AND METHODS OF MAKING AND USING THE SAME | Rib-X Pharmaceuticals, Inc. (US) | 2006-05-17 | — | — | EP | disclosed |
| US-6969726-B2 | Biaryl heterocyclic compounds and methods of making and using the same | MELINTA SUBSIDIARY CORP. | 2005-11-29 | — | — | US | disclosed |
| US-20050203147-A1 | Biaryl heterocyclic compounds and methods of making and using the same | MELINTA SUBSIDIARY CORP. | 2005-09-15 | — | — | US | disclosed |
| WO-2005066217-A1 | METHOD FOR THE PREPARATION OF RESIN-REINFORCED AQUEOUS POLYMERIC DISPERSIONS | UNIVERSIDAD DEL PAIS VASCO EUSKAL HERRIKO UNIBERTSITATEA (ES) | 2005-07-21 | — | — | WO | disclosed |
| WO-2005019211-A2 | BIARYL HETEROCYCLIC COMPOUNDS AND METHODS OF MAKING AND USING THE SAME | RIB-X PHARMACEUTICALS, INC. (US) | 2005-03-03 | — | — | WO | disclosed |
| US-20050043317-A1 | Biaryl heterocyclic compounds and methods of making and using the same | MELINTA SUBSIDIARY CORP. | 2005-02-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100234591-A1 | BIARYL HETEROCYCLIC COMPOUNDS AND METHODS OF MAKING AND USING THE SAME | PCNA, AADAC, MIF | MAOA 872/4885CALML3 3842/4885MAOB 994/4885 |
| US-20060264426-A1 | Biaryl heterocyclic compounds and methods of making and using the same | PCNA, AADAC, MIF | MAOA 872/4885CALML3 3842/4885MAOB 994/4885 |
| US-20150072970-A1 | BIARYL HETEROCYCLIC COMPOUNDS AND METHODS OF MAKING AND USING THE SAME | PCNA, AADAC, MIF | MAOA 872/4885CALML3 3842/4885MAOB 994/4885 |
| US-20050043317-A1 | Biaryl heterocyclic compounds and methods of making and using the same | PCNA, AADAC, MIF | MAOA 872/4885CALML3 3842/4885MAOB 994/4885 |
| US-20120010200-A1 | Biaryl Heterocyclic Compounds And Methods Of Making And Using The Same | PCNA, AADAC, MIF | MAOA 872/4885CALML3 3842/4885MAOB 994/4885 |
| US-20140073624-A1 | Biaryl Heterocyclic Compounds and Methods of Making and Using the Same | PCNA, AADAC, MIF | MAOA 872/4885CALML3 3842/4885MAOB 994/4885 |
| US-20050203147-A1 | Biaryl heterocyclic compounds and methods of making and using the same | PCNA, AADAC, MIF | MAOA 872/4885CALML3 3842/4885MAOB 994/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.