Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 5/20 | 0.58 |
| ▸ | CALML3 | P27482 | 7/20 | 0.55 |
| ▸ | MAOB | P27338 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.55 |
| ▸ | SDHA | P31040 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5173460 | 1.00 | MAOA (0.58) | MAOACALML3MAOBLMNAPTGS1 | |
| SCHEMBL10266866 | 0.91 | MAOA (0.64) | MAOACALML3MAOBLMNAPTGS1 | |
| SCHEMBL1394562 | 0.91 | MAOA (0.59) | MAOACALML3MAOBLMNAPTGS1 | |
| SCHEMBL4573648 | 0.86 | MAOA (0.64) | MAOACALML3MAOBLMNAPTGS1 | |
| SCHEMBL4573653 | 0.86 | MAOA (0.64) | MAOACALML3MAOBLMNAPTGS1 | |
| SCHEMBL5173464 | 0.86 | MAOA (0.57) | MAOACALML3MAOBLMNAPTGS1 | |
| SCHEMBL10259146 | 0.85 | MAOA (0.63) | MAOACALML3MAOBLMNAPTGS1 | |
| SCHEMBL14432500 | 0.84 | MAOA (0.59) | MAOACALML3MAOBLMNAPTGS1 | |
| SCHEMBL29308072 | 0.84 | MAOA (0.70) | MAOACALML3MAOBLMNAPTGS1 | |
| SCHEMBL14763076 | 0.84 | MAOA (0.55) | MAOACALML3MAOBLMNAPTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778653-A1 | BIARYL HETEROCYCLIC COMPOUNDS AND METHODS OF MAKING AND USING THE SAME | Rib-X Pharmaceuticals, Inc. (US) | 2007-05-02 | — | — | EP | disclosed |
| WO-2006022794-A1 | BIARYL HETEROCYCLIC COMPOUNDS AND METHODS OF MAKING AND USING THE SAME | RIB-X PHARMACEUTICALS, INC. (US) | 2006-03-02 | — | — | WO | disclosed |